Cerebral perfusion in the predementia stages of Alzheimer's disease.
Objectives: To investigate arterial spin-labelling (ASL) cerebral blood flow (CBF) changes in predementia stages of Alzheimer's disease (AD).Methods: Data were obtained from 177 patients with subjective complaints, mild cognitive impairment and AD from the Amsterdam Dementia Cohort. AD stages were b...
| Publicado en: | European Radiology Vol. 26; no. 2; pp. 506 - 515 |
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| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Feb2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=112262179&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 112262179 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Feb2016 vid: 26 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 112262179 112262179 NLM26040647 112262179 10.1007/s00330-015-3834-9 NLM26040647 PMC4712243 112262179 ppf: 506 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Cerebral perfusion in the predementia stages of Alzheimer's disease. aug: au: Binnewijzend, Maja Benedictus, Marije Kuijer, Joost Flier, Wiesje Teunissen, Charlotte Prins, Niels Wattjes, Mike Berckel, Bart Scheltens, Philip Barkhof, Frederik Binnewijzend, Maja A A Benedictus, Marije R Kuijer, Joost P A van der Flier, Wiesje M Teunissen, Charlotte E Prins, Niels D Wattjes, Mike P van Berckel, Bart N M affil: Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam, Alzheimercenter Amsterdam, VU University Medical Center, 1007 MB Amsterdam The Netherlands sug: subj: Cerebrovascular Circulation Physiology Magnetic Resonance Imaging Alzheimer's Disease Physiopathology Alzheimer's Disease Diagnosis Disease Progression Female Severity of Illness Indices Prospective Studies Aged Middle Age Free Radicals Cross Sectional Studies Male Questionnaires Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Objectives: To investigate arterial spin-labelling (ASL) cerebral blood flow (CBF) changes in predementia stages of Alzheimer's disease (AD).Methods: Data were obtained from 177 patients with subjective complaints, mild cognitive impairment and AD from the Amsterdam Dementia Cohort. AD stages were based on diagnosis and cerebrospinal fluid biomarkers amyloid-β (Aβ) and total-tau (tau). General-linear-models were used to assess relationships between AD stages and total and regional CBF, correcting for age and sex.Results: Decreasing CBF was related to more advanced AD stages in all supratentorial regions (p for trend < 0.05). Post-hoc testing revealed that CBF was lower in AD compared to controls and stage-1 predementia patients (i.e. abnormal Aβ and normal tau) in temporal and parietal regions, and compared to stage-2 predementia patients (i.e. abnormal Aβ and tau) in temporal regions. CBF values of stage-2 predementia patients were numerically in between those of stage-1 predementia patients and AD.Conclusion: The continuing decrease of CBF along the continuum of AD indicates the potential of ASL-CBF as a measure for disease progression.Key Points: • Decreasing CBF relates to more advanced AD stages in all supratentorial regions. • The reduction of CBF does not reach a bottom level. • ASL-CBF has potential as a measure for disease progression in AD. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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