Spinal Fluid Lactate Dehydrogenase Level Differentiates between Structural and Metabolic Etiologies of Altered Mental Status in Children.
Objective Altered mental status is a common cause of intensive care unit admission in children. Differentiating structural causes of altered mental status from metabolic etiologies is of utmost importance in diagnostic approach and management of the patients. Among many biomarkers proposed to help s...
| Publicado en: | Iranian Journal of Child Neurology Vol. 9; no. 1; pp. 31 - 37 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Iranian Journal of Child Neurology
Winter2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=112349346&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 112349346 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17354668 A91T jtl: Iranian Journal of Child Neurology issn: 17354668 maglogo: N pubinfo: dt: Winter2015 vid: 9 iid: 1 pid: 56766 pub: Iranian Journal of Child Neurology place: Tehran, <Blank> artinfo: ui: 112349346 112349346 112349346 112349346 ppf: 31 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Spinal Fluid Lactate Dehydrogenase Level Differentiates between Structural and Metabolic Etiologies of Altered Mental Status in Children. aug: au: KHOSROSHAHI, Nahid ALIZADEH, Parastoo KHOSRAVI, Mehdi SALAMATI, Peyman KAMRANI, Kamyar affil: Department of Pediatric Neurology, Tehran University of Medical Sciences, Tehran, Iran sug: subj: Organic Mental Disorders Etiology Organic Mental Disorders Diagnosis Cerebrospinal Fluid Analysis Lactate Dehydrogenase Cerebrospinal Fluid Brain Diseases, Metabolic Complications Human Brain Physiopathology Biological Markers Cerebrospinal Fluid Cross Sectional Studies Lactate Dehydrogenase Analysis Intensive Care Units, Pediatric Male Female Infant Child, Preschool Child Descriptive Statistics Brain Radiography P-Value Infant: 1-23 months Child, Preschool: 2-5 years Child: 6-12 years Male Female ab: Objective Altered mental status is a common cause of intensive care unit admission in children. Differentiating structural causes of altered mental status from metabolic etiologies is of utmost importance in diagnostic approach and management of the patients. Among many biomarkers proposed to help stratifying patients with altered mental status, spinal fluid lactate dehydrogenase appears to be the most promising biomarker to predict cellular necrosis. Materials & Methods In this cross sectional study we measured spinal fluid level of lactate dehydrogenase in children 2 months to 12 years of age admitted to a single center intensive care unit over one year. Spinal fluid level of lactate dehydrogenase in 40 pediatric cases of febrile seizure was also determined as th e control group. Results The study group included 35 boys (58.3%) and 25 girls (41.7%). Their mean age was 2.7+/-3 years and their mean spinal fluid lactate dehydrogenase level was 613.8+/-190.4 units/liter. The control group included 24 boys (55.8%) and 19 girls (44.2%). Their mean age was 1.3+/-1.2 years and their mean spinal fluid lactate dehydrogenase level was 18.9+/-7.5 units/liter. The mean spinal fluid lactate dehydrogenase level in children with abnormal head CT scan was 246.3+/-351.5 units/liter compared to 164.5+/-705.7 in those with normal CT scan of the head (p=0.001). Conclusion Spinal fluid lactate dehydrogenase level is useful in differentiating structural and metabolic causes of altered mental status in children. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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