The risk of overweight/obesity in mid-life and late life for the development of dementia: a systematic review and meta-analysis of longitudinal studies.
Scope: it has been suggested that overweight/obesity as a risk factor for incident dementia differs between mid-life and later life. We performed a systematic review and meta-analysis ofthe up-to-date current literature to assess this. Search Methods: inclusion criteria included epidemiological long...
| Publicado en: | Age & Ageing Vol. 45; no. 1; pp. 14 - 22 |
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| Autores principales: | , , |
| Formato: | Artículo |
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Oxford University Press / USA
Jan2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=112362603&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 112362603 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Jan2016 vid: 45 iid: 1 pid: 622 pub: Oxford University Press / USA artinfo: ui: 112362603 10.1093/ageing/afv151 ppf: 14 ppct: 8 formats: tig: atl: The risk of overweight/obesity in mid-life and late life for the development of dementia: a systematic review and meta-analysis of longitudinal studies. aug: au: PEDDITIZI, EMILIO PETERS, RUTH BECKETT, NIGEL affil: Medicine, Imperial College, London, UK Imperial College London, London, UK Care of the Elderly, Imperial College London, London, UK su: Dementia risk factors Obesity complications Confidence intervals Information storage & retrieval systems Medical databases Medical information storage & retrieval systems Psychology information storage & retrieval systems Longitudinal method MEDLINE Meta-analysis Online information services Systematic reviews sug: subj: Dementia risk factors Obesity complications Confidence intervals Information storage & retrieval systems Medical databases Medical information storage & retrieval systems Psychology information storage & retrieval systems Longitudinal method MEDLINE Meta-analysis Online information services Systematic reviews keyword: aged dementia obesity older people overweight systematic review aged dementia obesity older people overweight systematic review ab: Scope: it has been suggested that overweight/obesity as a risk factor for incident dementia differs between mid-life and later life. We performed a systematic review and meta-analysis ofthe up-to-date current literature to assess this. Search Methods: inclusion criteria included epidemiological longitudinal studies published up to September 2014, in participants without cognitive impairment based on evidence of cognitive assessment and aged 30 or over at baseline assessment with at least 2 years of follow-up. Pubmed, Medline, EMBASE, PsychInfo and the Cochrane Library were searched using combinations of the search terms: Dementia, Alzheimer disease, Vascular Dementia, Multi-Infarct Dementia, Cognitive decline, Cognitive impairment, Mild Cognitive Impairment/Obesity, Overweight, Adiposity, Waist circumference (limits: humans, English language). Handsearching of all papers meeting the inclusion criteria was performed. A random-effects model was used for the meta-analysis. Results: ofthe 1,612 abstracts identified and reviewed, 21 completely met the inclusion criteria. Being obese below the age of 65 years had a positive association on incident dementia with a risk ratio (RR) 1.41 (95% confidence interval, CI: 1.20-1.66), but the opposite was seen in those aged 65 and over, RR 0.83 (95% CI: 0.74-0.94). Conclusions: this systematic review and meta-analysis suggests a positive association between obesity in mid-life and later dementia but the opposite in late life. Whether weight reduction in mid-life reduces risk is worthy of further study. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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