Association between baseline peri-infarct magnetic resonance spectroscopy and regional white matter atrophy after stroke.
Introduction: Cerebral atrophy after stroke is associated with poor functional outcome. The prediction and prevention of post-stroke brain atrophy could therefore represent a target for neurorestorative therapies. We investigated the associations between peri-infarct metabolite concentrations measur...
| Publicado en: | Neuroradiology Vol. 58; no. 1; pp. 3 - 11 |
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| Autores principales: | , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jan2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=112455362&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 112455362 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Jan2016 vid: 58 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 112455362 112455362 112455362 10.1007/s00234-015-1593-6 112455362 ppf: 3 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Association between baseline peri-infarct magnetic resonance spectroscopy and regional white matter atrophy after stroke. aug: au: Yassi, Nawaf Campbell, Bruce Davis, Stephen Bivard, Andrew Moffat, Bradford Steward, Christopher Desmond, Patricia Churilov, Leonid Donnan, Geoffrey Parsons, Mark affil: Departments of Medicine and Neurology, Melbourne Brain Centre @ The Royal Melbourne Hospital, 4 Centre, The Royal Melbourne Hospital, Grattan St Parkville 3050 Australia sug: subj: Magnetic Resonance Spectroscopy Gray Matter Stroke Stroke Prevention and Control Stroke Patients ab: Introduction: Cerebral atrophy after stroke is associated with poor functional outcome. The prediction and prevention of post-stroke brain atrophy could therefore represent a target for neurorestorative therapies. We investigated the associations between peri-infarct metabolite concentrations measured by quantitative MRS and brain volume change in the infarct hemisphere after stroke. Methods: Twenty patients with ischemic stroke were enrolled. Patients underwent 3T-MRI within 1 week of onset, and at 1 and 3 months. At the baseline scan, an MRS voxel was placed manually in the peri-infarct area and another in the corresponding contralateral region. Volumetric analysis of T1 images was performed using two automated processing packages. Changes in gray and white matter volume were assessed as percentage change between 1 and 3 months. Results: Mean concentrations (institutional units) of N-acetylaspartic acid (NAA) (6.1 vs 7.0, p = 0.039), total creatine (Cr+PCr) (5.4 vs 5.8, p = 0.043), and inositol (4.5 vs 5.0, p = 0.014), were significantly lower in the peri-infarct region compared with the contralateral hemisphere. There was a significant correlation between baseline peri-infarct NAA and white matter volume change in the infarct hemisphere between 1 and 3 months, with lower NAA being associated with subsequent white matter atrophy (Spearman's rho = 0.66, p = 0.010). The baseline concentration of Cr+PCr was also significantly correlated with white matter atrophy in the infarct hemisphere (Spearman's rho = 0.59, p = 0.027). Both of these associations were significant after adjustment for the false discovery rate and were validated using the secondary volumetric method. Conclusion: MRS may be useful in the prediction of white matter atrophy post-stroke and in the testing of novel neurorestorative therapies. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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