Cross-validation of biomarkers for the early differential diagnosis and prognosis of dementia in a clinical setting.
Purpose: The aim of this study was to evaluate the supportive role of molecular and structural biomarkers (CSF protein levels, FDG PET and MRI) in the early differential diagnosis of dementia in a large sample of patients with neurodegenerative dementia, and in determining the risk of disease progre...
| Publicado en: | European Journal of Nuclear Medicine & Molecular Imaging Vol. 43; no. 3; pp. 499 - 509 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Mar2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=112693732&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 112693732 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16197070 NPC jtl: European Journal of Nuclear Medicine & Molecular Imaging issn: 16197070 maglogo: N pubinfo: dt: Mar2016 vid: 43 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 112693732 10.1007/s00259-015-3170-y 112693732 ppf: 499 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Cross-validation of biomarkers for the early differential diagnosis and prognosis of dementia in a clinical setting. aug: au: Perani, Daniela Cerami, Chiara Caminiti, Silvia Santangelo, Roberto Coppi, Elisabetta Ferrari, Laura Pinto, Patrizia Passerini, Gabriella Falini, Andrea Iannaccone, Sandro Cappa, Stefano Comi, Giancarlo Gianolli, Luigi Magnani, Giuseppe affil: Department of Neurology, San Raffaele Hospital, Via Olgettina, 60 20132 Milan Italy sug: ab: Purpose: The aim of this study was to evaluate the supportive role of molecular and structural biomarkers (CSF protein levels, FDG PET and MRI) in the early differential diagnosis of dementia in a large sample of patients with neurodegenerative dementia, and in determining the risk of disease progression in subjects with mild cognitive impairment (MCI). Methods: We evaluated the supportive role of CSF Aβ, t-Tau, p-Tau levels, conventional brain MRI and visual assessment of FDG PET SPM t-maps in the early diagnosis of dementia and the evaluation of MCI progression. Results: Diagnosis based on molecular biomarkers showed the best fit with the final diagnosis at a long follow-up. FDG PET SPM t-maps had the highest diagnostic accuracy in Alzheimer's disease and in the differential diagnosis of non-Alzheimer's disease dementias. The p-tau/Aβ ratio was the only CSF biomarker providing a significant classification rate for Alzheimer's disease. An Alzheimer's disease-positive metabolic pattern as shown by FDG PET SPM in MCI was the best predictor of conversion to Alzheimer's disease. Conclusion: In this clinical setting, FDG PET SPM t-maps and the p-tau/Aβ ratio improved clinical diagnostic accuracy, supporting the importance of these biomarkers in the emerging diagnostic criteria for Alzheimer's disease dementia. FDG PET using SPM t-maps had the highest predictive value by identifying hypometabolic patterns in different neurodegenerative dementias and normal brain metabolism in MCI, confirming its additional crucial exclusionary role. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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