Correlation of force control with regional spinal DTI in patients with cervical spondylosis without signs of spinal cord injury on conventional MRI.
Objectives: The aim of this study was to investigate spinal cord structure in patients with cervical spondylosis where conventional MRI fails to reveal spinal cord damage.Methods: We performed a cross-sectional study of patients with cervical spondylosis without conventional MRI findings of spinal c...
| Publicado en: | European Radiology Vol. 26; no. 3; pp. 733 - 743 |
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| Autores principales: | , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=112861112&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 112861112 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Mar2016 vid: 26 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 112861112 112861112 NLM26123409 112861112 10.1007/s00330-015-3876-z NLM26123409 112861112 ppf: 733 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Correlation of force control with regional spinal DTI in patients with cervical spondylosis without signs of spinal cord injury on conventional MRI. aug: au: Lindberg, Påvel Sanchez, Katherine Ozcan, Fidan Rannou, François Poiraudeau, Serge Feydy, Antoine Maier, Marc Lindberg, Påvel G Maier, Marc A affil: FR 3636 Neurosciences, Université Paris Descartes, Sorbonne Paris Cité, 45 rue des Saints Pères F-75006 Paris France sug: subj: Spondylosis Magnetic Resonance Imaging Methods Spinal Cord Magnetic Resonance Imaging Spondylosis Pathology Spinal Cord Pathology Female Middle Age Male Cross Sectional Studies Human Middle Aged: 45-64 years Female Male ab: Objectives: The aim of this study was to investigate spinal cord structure in patients with cervical spondylosis where conventional MRI fails to reveal spinal cord damage.Methods: We performed a cross-sectional study of patients with cervical spondylosis without conventional MRI findings of spinal cord damage and healthy controls. Subjects were studied using spinal diffusion tensor imaging (DTI), precision grip and foot force-tracking tasks, and a clinical examination including assessment of neurological signs. A regional analysis of lateral and medial spinal white matter across multiple cervical levels (C1-C5) was performed.Results: DTI revealed reduced fractional anisotropy (FA) and increased radial diffusivity (RD) in the lateral spinal cord at the level of greatest compression (lowest Pavlov ratio) in patients (p < 0.05). Patients with spondylosis had greater error and longer release duration in both grip and foot force-tracking. Similar spinal cord deficits were present in patients without neurological signs. Increased error in grip and foot tracking (low accuracy) correlated with increased RD in the lateral spinal cord at the level of greatest compression (p ≤ 0.01).Conclusions: Spinal DTI can detect subtle spinal cord damage of functional relevance in cervical spondylosis, even in patients without signs on conventional T2-imaging and without neurological signs.Key Points: DTI reveals spinal cord changes in cervical spondylosis with few symptoms. DTI changes were present despite normal spinal cord on conventional MRI. DTI parameters correlated with force control accuracy in hand and foot. Spinal DTI is a promising technique for patients with cervical spondylosis. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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