MDCT assessment of CAD in type-2 diabetic subjects with diabetic neuropathy: the role of Charcot neuro-arthropathy.
Objectives: To compare the CACS and CAD severity assessed by MDCT in neuropathic type-2 diabetic patients with and without Charcot-neuroarthropathy (CN).Methods: Thirty-four CN asymptomatic-patients and 36 asymptomatic-patients with diabetic-neuropathy (DN) without CN underwent MDCT to assess CACS a...
| Publicado en: | European Radiology Vol. 26; no. 3; pp. 788 - 797 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=112861124&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 112861124 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Mar2016 vid: 26 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 112861124 112861124 NLM26139314 112861124 10.1007/s00330-015-3864-3 NLM26139314 112861124 ppf: 788 ppct: 9 formats: fmt: @attributes: type: P tig: atl: MDCT assessment of CAD in type-2 diabetic subjects with diabetic neuropathy: the role of Charcot neuro-arthropathy. aug: au: Marano, Riccardo Pitocco, Dario Stasio, Enrico Savino, Giancarlo Merlino, Biagio Trani, Carlo Pirro, Federica Rutigliano, Claudia Santangelo, Carolina Minoiu, Aurelian Natale, Luigi Bonomo, Lorenzo Di Stasio, Enrico Minoiu, Aurelian Costin affil: Department of Radiological Sciences - Institute of Radiology, Catholic University of Rome, 'A. Gemelli' University Hospital, L.go Agostino Gemelli 8 00168 Rome Italy sug: subj: Arthropathy, Neurogenic Radiography Prospective Studies Risk Factors Diabetic Neuropathies Complications Amyotrophic Lateral Sclerosis Risk Factors Methods Prospective Studies Methods Diabetic Neuropathies Diabetes Mellitus, Type 2 Radiography Multidetector Computed Tomography Severity of Illness Indices Methods Arthropathy, Neurogenic Complications Diabetes Mellitus, Type 2 Coronary Angiography Multidetector Computed Tomography Methods Amyotrophic Lateral Sclerosis Radiography Severity of Illness Indices Coronary Arteriosclerosis Radiography Coronary Arteriosclerosis Complications Coronary Arteriosclerosis Diabetes Mellitus, Type 2 Complications Arthropathy, Neurogenic Diabetic Neuropathies Radiography Amyotrophic Lateral Sclerosis Complications Coronary Angiography Methods Female Male Middle Age Human Middle Aged: 45-64 years Female Male ab: Objectives: To compare the CACS and CAD severity assessed by MDCT in neuropathic type-2 diabetic patients with and without Charcot-neuroarthropathy (CN).Methods: Thirty-four CN asymptomatic-patients and 36 asymptomatic-patients with diabetic-neuropathy (DN) without CN underwent MDCT to assess CACS and severity of CAD. Patients were classified as positive for significant CAD in presence of at least one stenosis >50 % on MDCT-coronary-angiography (MDCT-CA). Groups were matched for age, sex and traditional CAD risk-factors. The coronary-angiography (CA) was performed in all patients with at least a significant stenosis detected by MDCT-CA, both as reference and eventually as treatment.Results: CN patients showed higher rates of significant CAD in comparison with DN subjects [p < 0.001], while non-significant differences were observed in CACS (p = 0.980). No significant differences were also observed in CACS distribution in all subjects for stenosis ≥/<50 % (p = 0.814), as well as in both groups (p = 0.661 and 0.559, respectively). The MDCT-CA showed an overall diagnostic-accuracy for significant CAD of 87%.Conclusions: These preliminary data suggest that CN-patients have a higher prevalence of severe CAD in comparison with DN-patients, while coronary plaques do not exhibit an increased amount of calcium. MDCT may be helpful to assess the CV risk in such asymptomatic type-2-diabetic patients with autonomic-neuropathy.Key Points: Type 2-diabetic-patients with CN result having more severe coronary artery plaque-burden. MDCT-CA may stratify the CV risk in type 2-diabetic-patients with CN. Adequate diagnostic is mandatory for optimal management of type 2-diabetic-patients with CN. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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