Transition States of Vicinal Diamine-Catalyzed Aldol Reactions.
The transition states of aldol reactions catalyzed by vicinal diamines are characterized with density functional calculations. It was found that a cyclic transition state involving a nine-membered hydrogen-bonded ring is preferred. The crown (chair-chair) conformations of the transition state accoun...
| Publicado en: | Journal of the American Chemical Society Vol. 138; no. 2; pp. 503 - 507 |
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| Autores principales: | , , |
| Formato: | Artículo |
| Publicado: |
American Chemical Society
1/20/2016
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| Sumario: | The transition states of aldol reactions catalyzed by vicinal diamines are characterized with density functional calculations. It was found that a cyclic transition state involving a nine-membered hydrogen-bonded ring is preferred. The crown (chair-chair) conformations of the transition state account for the observed stereoselectivity of these reactions. |
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