Multivitamins and minerals modulate whole-body energy metabolism and cerebral blood-flow during cognitive task performance: a double-blind, randomised, placebo-controlled trial.
Background: The brain is by far the most metabolically active organ in the body, with overall energy expenditure and local blood-supply closely related to neural activity. Both energy metabolism and cerebral vaso-dilation are dependent on adequate micronutrient status. This study investigated whethe...
| Published in: | Nutrition & Metabolism Vol. 13; pp. 1 - 17 |
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| Main Authors: | , , , , , , , , , , , |
| Format: | pictorial research tables/charts randomized controlled trial Journal Article |
| Published: |
BioMed Central
2/11/2016
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=112931020&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 112931020 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17437075 1CYX jtl: Nutrition & Metabolism issn: 17437075 maglogo: N pubinfo: dt: 2/11/2016 vid: 13 pid: 24147 pub: BioMed Central artinfo: ui: 112931020 112931020 112931020 10.1186/s12986-016-0071-4 112931020 ppf: 1 ppct: 16 formats: fmt: @attributes: type: P tig: atl: Multivitamins and minerals modulate whole-body energy metabolism and cerebral blood-flow during cognitive task performance: a double-blind, randomised, placebo-controlled trial. aug: au: Kennedy, David O. Stevenson, Emma J. Jackson, Philippa A. Dunn, Sarah Wishart, Karl Bieri, Gregor Barella, Luca Carne, Alexandra Dodd, Fiona L. Robertson, Bernadette C. Forster, Joanne Haskell-Ramsay, Crystal F. affil: Brain, Performance and Nutrition Research Centre, Northumbria University, Newcastle-upon-Tyne NE1 8ST, UK sug: subj: Micronutrients Minerals Metabolism Vitamins Metabolism Dietary Supplementation Brain Metabolism Energy Metabolism Cerebrovascular Circulation Task Performance and Analysis Cognition Human Randomized Controlled Trials Double-Blind Studies Female Adult Middle Age Descriptive Statistics Placebos Spectroscopy, Near-Infrared Calorimetry Methods Dose-Response Relationship, Drug Exploratory Research Vitamins Administration and Dosage Analysis of Variance Neuropsychological Tests Visual Analog Scaling Data Analysis Software Effect Size Post Hoc Analysis Analysis of Covariance T-Tests Funding Source Adult: 19-44 years Middle Aged: 45-64 years Female ab: Background: The brain is by far the most metabolically active organ in the body, with overall energy expenditure and local blood-supply closely related to neural activity. Both energy metabolism and cerebral vaso-dilation are dependent on adequate micronutrient status. This study investigated whether supplementation with ascending doses of multi-vitamin/minerals could modulate the metabolic and cerebral blood-flow consequences of performing cognitive tasks that varied in difficulty. Methods: In this randomised, double-blind, placebo-controlled, parallel-groups study 97 healthy females (25-49 y), who were not selected on the basis of any nutritional parameters, received either placebo or one of two doses of multivitamins/minerals. Cerebral blood-flow (CBF) parameters in the frontal cortex, and total energy expenditure (TotalEnergy), carbohydrate and fat oxidation (CarbOxi/FatOxi), were measured during 5 tasks of graded cognitive difficulty and a control task (5 min per task) using Near-infrared spectroscopy (NIRS) and Indirect calorimetry of exhaled pulmonary gas (ICa) respectively. Assessments took place 60 min after the first dose and following eight weeks supplementation. Results: During task performance supplementation with the first dose of micronutrients led to a dose-dependent increase in TotalEnergy and FatOxi throughout the post-dose assessment period following the higher dose, and increases in the total concentration of haemoglobin, a proxy measure for CBF, during task performance following the lower dose of vitamins/minerals (also containing coenzyme-Q10). Chronic supplementation over 8 weeks led to a dose-dependent increase in TotalEnergy during the task period. There were no interpretable effects on mood or cognitive performance. Conclusions: These results show that acute supplementation with micronutrients in healthy adults can modulate metabolic parameters and cerebral blood flow during cognitive task performance, and that the metabolic consequences are sustained during chronic supplementation. These findings suggest that both brain function and metabolism are amenable to micronutrient supplementation, even in adults who are assumed to have nutritional status typical of the population. pubtype: Academic Journal doctype: pictorial research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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