Interobserver agreement of confocal laser endomicroscopy for detection of head and neck neoplasia.
Objectives/hypothesis: We have described the feasibility of using the probe-based confocal laser endomicroscopy (pCLE) in differentiating benign from malignant lesions of the head and neck. Therefore, we wanted to determine the interobserver agreement of pCLE offline images of noncancerous, precance...
| Publicado en: | Laryngoscope Vol. 126; no. 3; pp. 632 - 638 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
Mar2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=112997560&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 112997560 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0023852X 1GR jtl: Laryngoscope issn: 0023852X maglogo: Y pubinfo: dt: Mar2016 vid: 126 iid: 3 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 112997560 112997560 NLM26372409 112997560 10.1002/lary.25646 NLM26372409 112997560 ppf: 632 ppct: 6 formats: tig: atl: Interobserver agreement of confocal laser endomicroscopy for detection of head and neck neoplasia. aug: au: Moore, Charles Mehta, Vikas Ma, Xiaohui Chaudhery, Shabnum Shi, Runhua Moore‐Medlin, Tara Lian, Timothy Nathan, Cherie‐Ann O. affil: Louisiana State University Health Shreveport School of Medicine, Louisiana State University Health Shreveport, Shreveport Louisiana, U.S.A. sug: subj: Carcinoma, Squamous Cell Pathology Videorecording Mucous Membrane Pathology Head and Neck Neoplasms Pathology Female Microscopy Methods Human Male Referral and Consultation Statistics and Numerical Data Biopsy, Needle Carcinoma, Squamous Cell Diagnosis Mucous Membrane Observer Bias Neoplasm Staging Confidence Intervals Neoplasm Invasiveness Pathology Immunohistochemistry Pilot Studies Hospitals, Special Head and Neck Neoplasms Diagnosis Validation Studies Comparative Studies Evaluation Research Multicenter Studies Female Male ab: Objectives/hypothesis: We have described the feasibility of using the probe-based confocal laser endomicroscopy (pCLE) in differentiating benign from malignant lesions of the head and neck. Therefore, we wanted to determine the interobserver agreement of pCLE offline images of noncancerous, precancerous, and cancerous lesions of the head and neck.Study Design: Single tertiary referral center.Methods: In the feasibility study, image criteria for nondysplasia, dysplasia, and cancer were defined. The pCLE was performed before lesions were biopsied. Fifty offline images and 10 videos of good quality were selected. Seven surgeons and one pathologist were asked to review and categorize the images into the three categories above. The overall accuracy of 29 offline pCLE images and six videos were compared with histopathology. Interobserver agreement and accuracy kappa (κ) scores were measured with 95% confidence intervals (CI).Results: There were six nondysplasia, seven dysplasia, and 11 squamous cell carcinoma (SCCA) cases, each with multiple images. There was substantial agreement between the eight reviewers on the pCLE images and videos (κ = 0.66; 95% CI 0.51-0.82 and κ = 0.71; 95% CI 0.42-0.97, respectively). The overall agreement with the final histopathology was also substantial for both the images and video sequences (κ = 0.70; 95% CI 0.50-0.88 and κ = 0.73; 95% CI 0.39-1.00, respectively).Conclusion: The ability to differentiate normal mucosa, dysplasia, and invasive SCCA using pCLE with high accuracy and reliability was demonstrated. This technology has the potential to decrease sampling error of lesions in the head and neck. This is the first study to test the reliability of this technology in mucosal lesions of the head and neck.Level Of Evidence: NA. Laryngoscope, 126:632-637, 2016. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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