Anatomical substrates and neurocognitive predictors of daily numerical abilities in mild cognitive impairment.
Patients with mild cognitive impairment experience difficulties in mathematics that affect their functioning in the activities of everyday life. What are the associated anatomical brain changes and the cognitive correlates underlying such deficits? In the present study, 33 patients with Mild Cogniti...
| Publicado en: | Cortex: A Journal Devoted to the Study of the Nervous System & Behavior Vol. 71; pp. 58 - 68 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Masson SPA
Oct 2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=113039806&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 113039806 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00109452 GMP jtl: Cortex: A Journal Devoted to the Study of the Nervous System & Behavior issn: 00109452 maglogo: N pubinfo: dt: Oct 2015 vid: 71 pid: 12473 pub: Masson SPA artinfo: ui: 113039806 113039806 NLM26159324 113039806 10.1016/j.cortex.2015.05.031 NLM26159324 113039806 ppf: 58 ppct: 10 formats: tig: atl: Anatomical substrates and neurocognitive predictors of daily numerical abilities in mild cognitive impairment. aug: au: Benavides-Varela, Silvia Burgio, Francesca Meneghello, Francesca De Marco, Matteo Arcara, Giorgio Rigon, Jessica Pilosio, Cristina Butterworth, Brian Venneri, Annalena Semenza, Carlo affil: IRCCS San Camillo Hospital Foundation, Neuropsychology Unit, Lido-Venice, Italy; Department of Developmental Psychology and Socialization, University of Padova, Italy sug: subj: Activities of Daily Living Psychosocial Factors Cognition Cognition Disorders Psychosocial Factors Cognition Disorders Pathology Predictive Value of Tests Magnetic Resonance Imaging Brain Pathology Neuropsychological Tests Language Tests Mathematics Female Gray Matter Pathology Aged, 80 and Over Aged Male Brain Mapping Human Clinical Assessment Tools Aged, 80 & over Aged: 65+ years Female Male ab: Patients with mild cognitive impairment experience difficulties in mathematics that affect their functioning in the activities of everyday life. What are the associated anatomical brain changes and the cognitive correlates underlying such deficits? In the present study, 33 patients with Mild Cognitive Impairments (MCI) and 29 cognitively normal controls underwent volumetric MRI, and completed the standardized battery of Numerical Activities of Daily Living (NADL) along with a comprehensive clinical neuropsychological assessment. Group differences were examined on the numerical tasks and volumetric brain measures. The gray (GM) and white matter (WM) volume correlates were also evaluated. The results showed that relative to controls, the MCI group had impairments in number comprehension, transcoding, written operations, and in daily activities involving time estimation and money usage. In the volumetric measures, group differences emerged for the transcoding subtask in the left insula and left superior temporal gyrus. Among MCI patients, number comprehension and formal numerical performance were correlated with volumetric variability in the right middle occipital areas and right frontal gyrus. Money-usage scores showed significant correlations with left mesial frontal cortex, right superior frontal and right superior temporal cortex. Regression models revealed that neuropsychological measures of long-term memory, language, visuo-spatial abilities, and abstract reasoning were predictive of the patients' decline in daily activities. The present findings suggest that early neuropathology in distributed cortical regions of the brain including frontal, temporal and occipital areas leads to a breakdown of cognitive abilities in MCI that impacts on numerical daily functioning. The findings have implications for diagnosis, clinical and domestic care of patients with MCI. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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