Analysis of the Expression and Function of Immunoglobulin-Like Transcript 4 (ILT4, LILRB2) in Dendritic Cells from Patients with Systemic Lupus Erythematosus.
Dendritic cells (DC) play an important role in the development and maintenance of immune tolerance. Although the inhibitory receptor ILT4/LILRB2 has been related with the tolerogenic phenotype of DC, the possible role of this receptor in the breakdown of DC tolerogenic function in systemic lupus ery...
| Publicado en: | Journal of Immunology Research pp. 1 - 14 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
2/22/2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=113218673&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 113218673 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23148861 GZMW jtl: Journal of Immunology Research issn: 23148861 maglogo: N pubinfo: dt: 2/22/2016 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 113218673 113218673 NLM27057555 113218673 10.1155/2016/4163094 NLM27057555 PMC4779820 113218673 ppf: 1 ppct: 13 formats: tig: atl: Analysis of the Expression and Function of Immunoglobulin-Like Transcript 4 (ILT4, LILRB2) in Dendritic Cells from Patients with Systemic Lupus Erythematosus. aug: au: Guerra-de Blas, Paola del Carmen Villaseñor-Talavera, Yael Sebastián Cruz-González, Daniela de Jesús Baranda, Lourdes Doníz-Padilla, Lesly Abud-Mendoza, Carlos González-Amaro, Roberto Monsiváis-Urenda, Adriana Elizabeth Villaseñor-Talavera, Yael Sebastián Cruz-González, Daniela de Jesús Doníz-Padilla, Lesly González-Amaro, Roberto Monsiváis-Urenda, Adriana Elizabeth affil: Departamento de Inmunología, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, Avenida Venustiano Carranza 2405, 78210 San Luis Potosí, SLP, Mexico sug: subj: Dendritic Cells Immunology Immune Tolerance Receptors, Cell Surface Metabolism Receptors, Cell Surface Membrane Glycoproteins Metabolism Membrane Glycoproteins Lupus Erythematosus, Systemic Immunology Female Dendritic Cells Drug Effects Adult Receptors, Cell Surface Immunology Lupus Erythematosus, Systemic Metabolism Phenotype Antigens, Surface Metabolism Lipopolysaccharides Immunology Dendritic Cells Metabolism Male Membrane Glycoproteins Immunology Antigens, Surface Immunology Cytokines Human Adult: 19-44 years Female Male ab: Dendritic cells (DC) play an important role in the development and maintenance of immune tolerance. Although the inhibitory receptor ILT4/LILRB2 has been related with the tolerogenic phenotype of DC, the possible role of this receptor in the breakdown of DC tolerogenic function in systemic lupus erythematosus (SLE) has not been elucidated. In this study, we analyzed the expression and function of the inhibitory receptor ILT4 in DC from SLE patients. We found that the percentage of ILT4 positive plasmacytoid DC and myeloid DC is significantly diminished in SLE patients. Interestingly, ligation of ILT4 did not affect the maturation or immunogenic capability of DC in healthy controls. In contrast, in SLE patients we observed an inhibitory effect of ILT4 on the immunogenic capability of DC. ILT4 was shown not to have a crucial role in regulating the maturation and function of DC from healthy controls but is partially involved in the maturation process and immunogenic capability of DC from SLE patients, suggesting that other inhibitory receptors, involved in the regulation of DC tolerogenic function, may be impaired in this autoimmune disease. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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