Predictive performance of glomerular filtration rate estimation equations based on cystatin C versus serum creatinine values in critically ill patients.
Purpose. The predictive performance of glomerular filtration rate (GFR) estimation equations based on cystatin C versus serum creatinine (SCr) values in critically ill patients was evaluated. Methods. A retrospective observational study was performed in the medical intensive care unit (ICU) of a uni...
| Publicado en: | American Journal of Health-System Pharmacy Vol. 73; no. 4; pp. 206 - 216 |
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| Autores principales: | , , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
2/15/2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=113282242&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 113282242 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10792082 1X3 jtl: American Journal of Health-System Pharmacy issn: 10792082 maglogo: N pubinfo: dt: 2/15/2016 vid: 73 iid: 4 pid: 622 pub: Oxford University Press / USA artinfo: ui: 113282242 113282242 113282242 10.2146/ajhp140852 113282242 ppf: 206 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Predictive performance of glomerular filtration rate estimation equations based on cystatin C versus serum creatinine values in critically ill patients. aug: au: Diego, Elisa Castro, Pedro Soy, Dolors Poch, Esteban Nicolás, Josep M. affil: Pharmacy Department, Hospital Clinic of Barcelona, Institut D'Investigacions Biomediques August Pi I Sunyer, University of Barcelona, Barcelona, Spain sug: subj: Glomerular Filtration Rate Critically Ill Patients Creatinine Blood Proteins Human Retrospective Design Nonexperimental Studies Intensive Care Units Academic Medical Centers Serum Albumin Blood Urea Nitrogen Creatinine Urine Data Analysis Software Descriptive Statistics Pearson's Correlation Coefficient Adolescence Adult Middle Age Aged Aged, 80 and Over Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over ab: Purpose. The predictive performance of glomerular filtration rate (GFR) estimation equations based on cystatin C versus serum creatinine (SCr) values in critically ill patients was evaluated. Methods. A retrospective observational study was performed in the medical intensive care unit (ICU) of a university hospital from October 2006 through September 2007. All consecutively admitted critically ill patients older than 18 years who stayed in the ICU for more than 48 hours with a urinary bladder catheter in place were included in the study. Data collected included SCr, cystatin C, serum albumin, blood urea nitrogen, and 24-hour urine creatinine clearance (CL...) levels. The following equations were also used to determine the estimated GFR that was compared with the reference CL... for all patients in the study: Arnal-Dade using cystatin C, Cockcroft-Gault using actual body weight, Cockcroft-Gault using ideal body weight, Jelliffe, Modification of Diet in Renal Disease (MDRD), and four-variable version MDRD (MDRD-4). Results. This study included 241 measurements corresponding to 131 critically ill patients. The cystatin C-based equation underestimated CL..., whereas overestimation by every SCr-based formula was observed in the whole cohort and in the CL...< 60 mL/min/1.73 m² subgroup; MDRD-4 was the most biased equation in every analysis. There were no significant differences in precision, except for great variability in the subgroup with a CL... of <60 mL/min/1.73 m ², where the MDRD equation showed better results than the cystatin C-based equation (33.5% versus 38.9%). No equations fulfilled concordance requirements with CL.... Conclusion. A retrospective observational study showed no evidence of superiority of a cystatin C-based equation over SCr-based equations to estimate the GFR in an ICU population. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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