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Silent Encoding of Chemical Post-Translational Modifications in Phage-Displayed Libraries.

In vitro selection of chemically modified peptide libraries presented on phage, while a powerful technology, is limited to one chemical post-translational modification (cPTM) per library. We use unique combinations of redundant codons to encode cPTMs with "silent barcodes" to trace multiple modifica...

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Published in:Journal of the American Chemical Society Vol. 138; no. 1; pp. 32 - 36
Main Authors: Tjhung, Katrina F., Kitov, Pavel I., Ng, Simon, Kitova, Elena N., Lu Deng, Klassen, John S., Derda, Ratmir
Format: Article
Published: American Chemical Society 1/13/2016
Subjects:
Bacteriophages
Microbial peptides
Genetic code
Carbonic anhydrase
Sulfonamides
Online Access:View this record in EBSCOhost

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