Decreasing ADHD phenotypic heterogeneity: searching for neurobiological underpinnings of the restrictive inattentive phenotype.
During the process of developing the DSM-5, a new phenotype of ADHD was proposed-the ADHD restrictive inattentive presentation (ADHD-RI), describing subjects with high endorsement of inattentive symptoms and a low level of hyperactivity. However, this phenotype was not included in the DSM-5 because...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 25; no. 3; pp. 273 - 283 |
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| Autores principales: | , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=113394070&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 113394070 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Mar2016 vid: 25 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 113394070 113394070 113394070 10.1007/s00787-015-0731-3 113394070 ppf: 273 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Decreasing ADHD phenotypic heterogeneity: searching for neurobiological underpinnings of the restrictive inattentive phenotype. aug: au: Ercan, Eyup Suren, Serkan Bacanlı, Ali Yazici, Kemal Callı, Cem Ozyurt, Onur Aygunes, Duygu Kosova, Buket Franco, Alexandre Rohde, Luis affil: Child and Adolescent Psychiatry Department, Medical Faculty, Ege University, Izmir Turkey sug: subj: Attention Deficit Hyperactivity Disorder Familial and Genetic Phenotype Human Comparative Studies Attention Deficit Hyperactivity Disorder Classification Child Adolescence Neuropsychological Tests Magnetic Resonance Imaging Polymorphism, Genetic Turkiye Child Behavior Checklist Checklists Scales Semi-Structured Interview Interview Guides Descriptive Statistics Genotype Saliva Analysis One-Way Analysis of Variance Multivariate Analysis of Covariance Post Hoc Analysis Chi Square Test Multiple Regression Male Female Intelligence Tests Funding Source Child: 6-12 years Adolescent: 13-18 years Male Female ab: During the process of developing the DSM-5, a new phenotype of ADHD was proposed-the ADHD restrictive inattentive presentation (ADHD-RI), describing subjects with high endorsement of inattentive symptoms and a low level of hyperactivity. However, this phenotype was not included in the DSM-5 because of the lack of robust neurobiological data. We aimed to assess the specific neurobiological underpinnings of individuals presenting ADHD-RI. We compared a sample of 301 subjects (101 ADHD-Combined; 50 ADHD-RI; 50 ADHD predominantly inattentive type and 100 typically developing subjects) aged 8-15 years, using a complete neuropsychological battery, molecular genetic data ( DRD4 and DAT1 most studied polymorphisms) and functional MRI during a Go-No/Go task. Subjects with ADHD-RI had a significantly different neuropsychological profile compared with the other groups, including lower psychomotor speeds, longer reaction times and the worst overall performance in the global neurocognitive index. The proportion of subjects with the presence of DRD4-7 repeat allele was significantly higher in ADHD-RI. The fMRI data suggested that more attention-related posterior brain regions (especially temporo-occipital areas) are activated in ADHD-RI during both Go and No-Go cues compared to TD controls and ADHD predominantly inattentive type. ADHD-RI may represent a different phenotype than other types of ADHD. In addition, our results suggest that reducing the phenotypic heterogeneity may aid in the search for the neurobiological underpinnings of ADHD. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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