Archeological Echocardiography: Digitization and Speckle Tracking Analysis of Archival Echocardiograms in the Hyper GEN Study.
Background Several large epidemiologic studies and clinical trials have included echocardiography, but images were stored in analog format and these studies predated tissue Doppler imaging ( TDI) and speckle tracking echocardiography ( STE). We hypothesized that digitization of analog echocardiogram...
| Published in: | Echocardiography Vol. 33; no. 3; pp. 386 - 398 |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
Mar2016
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=113444936&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 113444936 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07422822 GSE jtl: Echocardiography issn: 07422822 maglogo: Y pubinfo: dt: Mar2016 vid: 33 iid: 3 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 113444936 113444936 113444936 10.1111/echo.13095 113444936 ppf: 386 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Archeological Echocardiography: Digitization and Speckle Tracking Analysis of Archival Echocardiograms in the Hyper GEN Study. aug: au: Aguilar, Frank G. Selvaraj, Senthil Martinez, Eva E. Katz, Daniel H. Beussink, Lauren Kim, Kwang‐Youn A. Ping, Jie Rasmussen‐Torvik, Laura Goyal, Amita Sha, Jin Irvin, Marguerite R. Arnett, Donna K. Shah, Sanjiv J. affil: Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago Illinois sug: subj: Echocardiography Methods Image Processing, Computer Assisted Methods Digitizers Utilization Secondary Analysis Human Female Male Record Review Descriptive Statistics Data Analysis Software Pearson's Correlation Coefficient Intrarater Reliability Interrater Reliability P-Value Adult Middle Age Aged Reproducibility of Results Confidence Intervals Odds Ratio Post Hoc Analysis Pilot Studies Funding Source Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Female Male ab: Background Several large epidemiologic studies and clinical trials have included echocardiography, but images were stored in analog format and these studies predated tissue Doppler imaging ( TDI) and speckle tracking echocardiography ( STE). We hypothesized that digitization of analog echocardiograms, with subsequent quantification of cardiac mechanics using STE, is feasible, reproducible, accurate, and produces clinically valid results. Methods In the NHLBI Hyper GEN study (N = 2234), archived analog echocardiograms were digitized and subsequently analyzed using STE to obtain tissue velocities/strain. Echocardiograms were assigned quality scores and inter-/intra-observer agreement was calculated. Accuracy was evaluated in: (1) a separate second study (N = 50) comparing prospective digital strain versus post hoc analog-to-digital strain, and (2) in a third study (N = 95) comparing prospectively obtained TDI e' velocities with post hoc STE e' velocities. Finally, we replicated previously known associations between tissue velocities/strain, conventional echocardiographic measurements, and clinical data. Results Of the 2234 Hyper GEN echocardiograms, 2150 (96.2%) underwent successful digitization and STE analysis. Inter/intra-observer agreement was high for all STE parameters, especially longitudinal strain ( LS). In accuracy studies, LS performed best when comparing post hoc STE to prospective digital STE for strain analysis. STE-derived e' velocities correlated with, but systematically underestimated, TDI e' velocity. Several known associations between clinical variables and cardiac mechanics were replicated in Hyper GEN. We also found a novel independent inverse association between fasting glucose and LS (adjusted β = −2.4 [95% CI −3.6, −1.2]% per 1- SD increase in fasting glucose; P < 0.001). Conclusions Archeological echocardiography, the digitization and speckle tracking analysis of archival echocardiograms, is feasible and generates indices of cardiac mechanics similar to contemporary studies. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|