Can we improve accuracy and reliability of MRI interpretation in children with optic pathway glioma? Proposal for a reproducible imaging classification.

Introduction: Magnetic resonance (MR) images from children with optic pathway glioma (OPG) are complex. We initiated this study to evaluate the accuracy of MR imaging (MRI) interpretation and to propose a simple and reproducible imaging classification for MRI. Methods: We randomly selected 140 MRIs...

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Publicado en:Neuroradiology Vol. 58; no. 2; pp. 197 - 209
Autores principales: Rakotonjanahary, Josué, Lambron, Julien, Frampas, Eric, Toulgoat, Frédérique, Loisel, Didier, Carli, Emilie, Rialland, Xavier, Delion, Matthieu
Formato: diagnostic images research tables/charts Journal Article
Publicado: Springer Nature Feb2016
Acceso en línea:Ver este registro en EBSCOhost
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        10.1007/s00234-015-1612-7
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        atl: Can we improve accuracy and reliability of MRI interpretation in children with optic pathway glioma? Proposal for a reproducible imaging classification.
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          Rakotonjanahary, Josué
          Lambron, Julien
          Frampas, Eric
          Toulgoat, Frédérique
          Loisel, Didier
          Carli, Emilie
          Rialland, Xavier
          Delion, Matthieu
        affil: Department of Radiology, University Hospital, 1 Place Alexis-Ricordeau 44093 Nantes Cedex 1 France
      sug:
        subj:
          Optic Nerve Diseases Diagnosis
          Glioma Diagnosis
          Magnetic Resonance Imaging Methods
          Image Interpretation, Computer Assisted Methods
          Human
          Child
          Radiologists
          Neuroradiography
          Intrarater Reliability
          Interrater Reliability
          kappa Statistic
          Consensual Validity
          Descriptive Statistics
          Child: 6-12 years
      ab: Introduction: Magnetic resonance (MR) images from children with optic pathway glioma (OPG) are complex. We initiated this study to evaluate the accuracy of MR imaging (MRI) interpretation and to propose a simple and reproducible imaging classification for MRI. Methods: We randomly selected 140 MRIs from among 510 MRIs performed on 104 children diagnosed with OPG in France from 1990 to 2004. These images were reviewed independently by three radiologists (F.T., 15 years of experience in neuroradiology; D.L., 25 years of experience in pediatric radiology; and J.L., 3 years of experience in radiology) using a classification derived from the Dodge and modified Dodge classifications. Intra- and interobserver reliabilities were assessed using the Bland-Altman method and the kappa coefficient. These reviews allowed the definition of reliable criteria for MRI interpretation. Results: The reviews showed intraobserver variability and large discrepancies among the three radiologists (kappa coefficient varying from 0.11 to 1). These variabilities were too large for the interpretation to be considered reproducible over time or among observers. A consensual analysis, taking into account all observed variabilities, allowed the development of a definitive interpretation protocol. Using this revised protocol, we observed consistent intra- and interobserver results (kappa coefficient varying from 0.56 to 1). The mean interobserver difference for the solid portion of the tumor with contrast enhancement was 0.8 cm (limits of agreement = −16 to 17). Conclusion: We propose simple and precise rules for improving the accuracy and reliability of MRI interpretation for children with OPG. Further studies will be necessary to investigate the possible prognostic value of this approach.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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