Antifungal Saponins from the Maya Medicinal Plant Cestrum schlechtendahlii G. Don (Solanaceae).
Bioassay-guided fractionation of the crude extract (80% EtOH) of the leaves of Cestrum schlechtendahlii, a plant used by Q'eqchi' Maya healers for treatment of athlete's foot, resulted in the isolation and identification of two spirostanol saponins (1 and 2). Structure elucidation by MS, 1D-NMR, and...
| Publicado en: | Phytotherapy Research Vol. 30; no. 3; pp. 439 - 447 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
Mar2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=113445264&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 113445264 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0951418X O9B jtl: Phytotherapy Research issn: 0951418X maglogo: Y pubinfo: dt: Mar2016 vid: 30 iid: 3 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 113445264 113445264 NLM26666462 113445264 10.1002/ptr.5545 NLM26666462 113445264 ppf: 439 ppct: 8 formats: tig: atl: Antifungal Saponins from the Maya Medicinal Plant Cestrum schlechtendahlii G. Don (Solanaceae). aug: au: Ta, Chieu Anh Kim Guerrero ‐ Analco, J. Antonio Roberts, Elizabeth Liu, Rui Mogg, Christopher D. Saleem, Ammar Otárola ‐ Rojas, Marco Poveda, Luis Sanchez ‐ Vindas, Pablo Cal, Victor Caal, Federico Subramaniam, Rajagopal Smith, Myron L. Arnason, John T. affil: Laboratory for Analysis of Natural and Synthetic Environmental Toxins (LANSET), Department of Biology, University of Ottawa, Ottawa Canada sug: subj: Steroids Pharmacodynamics Antifungal Agents Pharmacodynamics Glycosides Pharmacodynamics Plant Extracts Pharmacodynamics Plants Fungi Drug Effects Medicine, Traditional Yeasts Drug Effects Steroids Candida Albicans Drug Effects Medicine, Herbal Plants, Medicinal Molecular Structure Plant Leaves Microbial Culture and Sensitivity Tests Plant Extracts Glycosides Ethnic Groups Antifungal Agents Cryptococcus Drug Effects Magnetic Resonance Spectroscopy ab: Bioassay-guided fractionation of the crude extract (80% EtOH) of the leaves of Cestrum schlechtendahlii, a plant used by Q'eqchi' Maya healers for treatment of athlete's foot, resulted in the isolation and identification of two spirostanol saponins (1 and 2). Structure elucidation by MS, 1D-NMR, and 2D-NMR spectroscopic methods identified them to be the known saponin (25R)-1β,2α-dihydroxy-5α-spirostan-3-β-yl-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-galactopyranoside (1) and new saponin (25R)-1β,2α-dihydroxy-5α-spirostan-3-β-yl-O-β-D-galactopyranoside (2). While 2 showed little or no antifungal activity at the highest concentration tested, 1 inhibited growth of Saccharomyces cerevisiae (minimum inhibitory concentration (MIC) of 15-25 μM), Candida albicans, Cryptococcus neoformans, and Fusarium graminearum (MIC of 132-198 μM). pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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