Inhibition of Helicobacter pylori and Its Associate Urease by Labdane Diterpenoids Isolated from Andrographis paniculata.
The present study was carried out to evaluate anti-Helicobacter pylori and its associated urease activity of labdane diterpenoids isolated from Andrographis paniculata. A molecular docking analysis was performed by using ArgusLab 4.0.1 software. The results obtained indicate that compound A possesse...
| Publicado en: | Phytotherapy Research Vol. 30; no. 3; pp. 412 - 418 |
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| Autores principales: | , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Mar2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=113445267&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 113445267 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0951418X O9B jtl: Phytotherapy Research issn: 0951418X maglogo: Y pubinfo: dt: Mar2016 vid: 30 iid: 3 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 113445267 113445267 NLM26648323 113445267 10.1002/ptr.5542 NLM26648323 113445267 ppf: 412 ppct: 6 formats: tig: atl: Inhibition of Helicobacter pylori and Its Associate Urease by Labdane Diterpenoids Isolated from Andrographis paniculata. aug: au: Shaikh, Rafik U. Dawane, Ashwini A. Pawar, Rajendra P. Gond, Dhananjay S. Meshram, Rohan J. Gacche, Rajesh N. affil: Department of Botany, Poona College, Camp, Pune 411 001, MS, India sug: subj: Hydrocarbons Pharmacodynamics Urease Antagonists and Inhibitors Antibiotics Pharmacodynamics Plant Extracts Pharmacodynamics Helicobacter Pylori Drug Effects Plants Antibiotics Helicobacter Pylori Bacterial Proteins Antagonists and Inhibitors Computer Simulation Hydrocarbons Microbial Culture and Sensitivity Tests Molecular Structure ab: The present study was carried out to evaluate anti-Helicobacter pylori and its associated urease activity of labdane diterpenoids isolated from Andrographis paniculata. A molecular docking analysis was performed by using ArgusLab 4.0.1 software. The results obtained indicate that compound A possesses strong inhibition to H. pylori, 28 ± 2.98 (minimum inhibitory concentration, 9 µg/mL), and its urease, 85.54 ± 2.62% (IC50 , 20.2 µg/mL). Compounds B, C, and D also showed moderate inhibition to H. pylori and its urease. The obtained results were in agreement with the molecular docking analysis of compounds. The phytochemicals under investigation were found to be promising antibacterial agents. Moreover, the isolated compounds can be considered as a resource for searching novel anti-H. pylori agents possessing urease inhibition. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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