Quantitative susceptibility mapping in patients with systemic lupus erythematosus: detection of abnormalities in normal-appearing basal ganglia.
Objectives: To evaluate whether quantitative susceptibility mapping (QSM) can be employed to detect abnormalities within normal-appearing basal ganglia on conventional MRI in patients with neuropsychiatric systemic lupus erythematosus (NPSLE).Methods: For 33 SLE patients (13 NPSLE and 20 non-NPSLE p...
| Publicado en: | European Radiology Vol. 26; no. 4; pp. 1056 - 1064 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Apr2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=113486836&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 113486836 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Apr2016 vid: 26 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 113486836 113486836 NLM26228900 10.1007/s00330-015-3929-3 NLM26228900 113486836 ppf: 1056 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Quantitative susceptibility mapping in patients with systemic lupus erythematosus: detection of abnormalities in normal-appearing basal ganglia. aug: au: Ogasawara, Atsushi Kakeda, Shingo Watanabe, Keita Ide, Satoru Ueda, Issei Murakami, Yu Moriya, Junji Futatsuya, Koichiro Sato, Toru Nakayamada, Shingo Saito, Kazuyoshi Tanaka, Yoshiya Liu, Tian Wang, Yi Korogi, Yukunori affil: Department of Radiology, University of Occupational and Environmental Health, School of Medicine, 1-1 Iseigaoka, Yahatanishi-ku Kitakyushu 807-8555 Japan sug: subj: Brain Mapping Methods Lupus Erythematosus, Systemic Pathology Basal Ganglia Pathology Magnetic Resonance Imaging Methods Observer Bias Reproducibility of Results Female Retrospective Design Male Adult Adult: 19-44 years Female Male ab: Objectives: To evaluate whether quantitative susceptibility mapping (QSM) can be employed to detect abnormalities within normal-appearing basal ganglia on conventional MRI in patients with neuropsychiatric systemic lupus erythematosus (NPSLE).Methods: For 33 SLE patients (13 NPSLE and 20 non-NPSLE patients) and 23 age/sex-matched controls, two radiologists independently measured the mean QSM and R2* values in various brain structures that appeared to be normal on conventional MR images. These values in each brain structure were compared among the two SLE groups and controls.Results: Regarding the putamen, the NPSLE patients showed significantly higher QSM values than the non-NPSLE patients and controls (p < 0.05). For the lateral globus pallidus, both SLE groups showed significantly higher QSM values than the controls (p < 0.05). The R2* values were not significantly different between both SLE groups. The NPSLE patients showed a significant correlation between the mean QSM values in putamen and the disease duration (r = 0.63, p < 0.05). For the interobserver agreement, the QSM value was superior to the R2* value (0.690 vs. 0.446, Kendall W value).Conclusions: QSM can be used to identify increased susceptibility of the basal ganglia appearing to be normal on conventional MR images in NPSLE patients.Key Points: • QSM values in the putamen are significantly higher in NPSLE than non-NPSLE. • NPSLE patients show correlation between QSM values in the putamen and disease duration. • QSM is more sensitive than R2* mapping for detecting subtle changes. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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