Implantable neurotechnologies: a review of integrated circuit neural amplifiers.
Neural signal recording is critical in modern day neuroscience research and emerging neural prosthesis programs. Neural recording requires the use of precise, low-noise amplifier systems to acquire and condition the weak neural signals that are transduced through electrode interfaces. Neural amplifi...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 54; no. 1; pp. 45 - 63 |
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| Autores principales: | , , , , , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
Springer Nature
Jan2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=113529490&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 113529490 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Jan2016 vid: 54 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 113529490 113529490 NLM26798055 113529490 10.1007/s11517-015-1431-3 NLM26798055 PMC4958006 113529490 ppf: 45 ppct: 18 formats: fmt: @attributes: type: P tig: atl: Implantable neurotechnologies: a review of integrated circuit neural amplifiers. aug: au: Ng, Kian Greenwald, Elliot Xu, Yong Ping Thakor, Nitish Ng, Kian Ann Thakor, Nitish V affil: Department of Biomedical Engineering, Johns Hopkins University, Baltimore 21205 USA sug: subj: Brain Physiology Technology Prostheses and Implants Evaluation Research ab: Neural signal recording is critical in modern day neuroscience research and emerging neural prosthesis programs. Neural recording requires the use of precise, low-noise amplifier systems to acquire and condition the weak neural signals that are transduced through electrode interfaces. Neural amplifiers and amplifier-based systems are available commercially or can be designed in-house and fabricated using integrated circuit (IC) technologies, resulting in very large-scale integration or application-specific integrated circuit solutions. IC-based neural amplifiers are now used to acquire untethered/portable neural recordings, as they meet the requirements of a miniaturized form factor, light weight and low power consumption. Furthermore, such miniaturized and low-power IC neural amplifiers are now being used in emerging implantable neural prosthesis technologies. This review focuses on neural amplifier-based devices and is presented in two interrelated parts. First, neural signal recording is reviewed, and practical challenges are highlighted. Current amplifier designs with increased functionality and performance and without penalties in chip size and power are featured. Second, applications of IC-based neural amplifiers in basic science experiments (e.g., cortical studies using animal models), neural prostheses (e.g., brain/nerve machine interfaces) and treatment of neuronal diseases (e.g., DBS for treatment of epilepsy) are highlighted. The review concludes with future outlooks of this technology and important challenges with regard to neural signal amplification. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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