Determination of the unmetabolised (18)F-FDG fraction by using an extension of simplified kinetic analysis method: clinical evaluation in paragangliomas.
Tumours with high (18)F-FDG uptake values on static late PET images do not always exhibit high proliferation indices. These discrepancies might be related to high proportion of unmetabolised (18)F-FDG components in the tissues. We propose a method that enables to calculate different (18)F-FDG kineti...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 54; no. 1; pp. 103 - 112 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jan2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=113529503&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 113529503 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Jan2016 vid: 54 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 113529503 113529503 NLM26044552 113529503 10.1007/s11517-015-1318-3 NLM26044552 PMC4670610 113529503 ppf: 103 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Determination of the unmetabolised (18)F-FDG fraction by using an extension of simplified kinetic analysis method: clinical evaluation in paragangliomas. aug: au: Barbolosi, Dominique Hapdey, Sebastien Battini, Stephanie Faivre, Christian Mancini, Julien Pacak, Karel Farman-Ara, Bardia Taïeb, David Taïeb, David affil: Department of Pharmacokinetics, UMR INSERM 911 CRO2, SMARTc, Faculty of Medicine-Pharmacy, Aix-Marseille University, 27, Boulevard Jean Moulin 13385 Marseille Cedex 5 France sug: subj: Paraganglioma Metabolism Brain Neoplasms Metabolism Fludeoxyglucose F 18 Metabolism Diagnostic Imaging Case Control Studies Tomography, Emission-Computed Fludeoxyglucose F 18 Pharmacokinetics Human Paraganglioma Tomography, X-Ray Computed Brain Neoplasms Validation Studies Comparative Studies Evaluation Research Multicenter Studies Clinical Assessment Tools Scales ab: Tumours with high (18)F-FDG uptake values on static late PET images do not always exhibit high proliferation indices. These discrepancies might be related to high proportion of unmetabolised (18)F-FDG components in the tissues. We propose a method that enables to calculate different (18)F-FDG kinetic parameters based on a new mathematical approach that integrates a measurement error model. Six patients with diagnosed non-metastatic paragangliomas (PGLs) and six control patients with different types of lesions were investigated in this pilot study using (18)F-FDG PET/CT. In all cases, a whole-body acquisition was followed by four static acquisitions centred over the target lesions, associated with venous blood samplings. We used an extension of the Hunter's method to calculate the net influx rate constant (K H). The exact net influx rate constant and vascular volume fraction (K i and V, respectively) were subsequently obtained by the method of least squares. Next, we calculated the mean percentages of metabolised (PM) and unmetabolised (PUM) (18)F-FDG components, and the times required to reach 80 % of the amount of metabolised (18)F-FDG (T80%). A test-retest evaluation indicated that the repeatability of our approach was accurate; the coefficients of variation were below 2 % regardless of the kinetic parameters considered. We observed that the PGLs were characterised by high dispersions of the maximum standardised uptake value SUVmax (9.7 ± 11, coefficient of variation CV = 114 %), K i (0.0137 ± 0.0119, CV = 87 %), and V (0.292 ± 0.306, CV = 105 %) values. The PGLs were associated with higher PUM (p = 0.02) and T80% (p = 0.02) values and lower k 3 (p = 0.02) values compared to the malignant lesions despite the similar SUVmax values (p = 0.55). The estimations of these new kinetic parameters are more accurate than SUVmax or K i for in vivo metabolic assessment of PGLs at the molecular level. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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