Functional neuroanatomical correlates of episodic memory impairment in early phase psychosis.
Studies have demonstrated that episodic memory (EM) is often preferentially disrupted in schizophrenia. The neural substrates that mediate EM impairment in this illness are not fully understood. Several functional magnetic resonance imaging (fMRI) studies have employed EM probe tasks to elucidate th...
| Publicado en: | Brain Imaging & Behavior Vol. 10; no. 1; pp. 1 - 12 |
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| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Mar2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=113546387&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 113546387 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Mar2016 vid: 10 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 113546387 113546387 NLM25749917 113546387 10.1007/s11682-015-9357-9 NLM25749917 PMC4561590 [Available on 03/01/17] 113546387 ppf: 1 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Functional neuroanatomical correlates of episodic memory impairment in early phase psychosis. aug: au: Francis, Michael Hummer, Tom Vohs, Jenifer Yung, Matthew Liffick, Emily Mehdiyoun, Nicole Radnovich, Alexander McDonald, Brenna Saykin, Andrew Breier, Alan Francis, Michael Matthew Hummer, Tom A Vohs, Jenifer L Yung, Matthew G Mehdiyoun, Nicole F Radnovich, Alexander J McDonald, Brenna C Saykin, Andrew J affil: Indiana University Psychotic Disorders Program, Department of Psychiatry, Indiana University School of Medicine, Indianapolis USA sug: subj: Memory Memory Disorders Physiopathology Schizophrenia Physiopathology Brain Physiopathology Visual Perception Physiology Psychotic Disorders Physiopathology Magnetic Resonance Imaging Brain Mapping Female Brain Drug Effects Young Adult Psychology Schizophrenia Drug Therapy Human Acute Disease Reaction Time Recognition (Psychology) Neuropsychological Tests Neural Pathways Physiopathology Neural Pathways Drug Effects Memory Disorders Drug Therapy Adolescence Psychotic Disorders Psychosocial Factors Psychotic Disorders Drug Therapy Adult Male Validation Studies Comparative Studies Evaluation Research Multicenter Studies Funding Source Adolescent: 13-18 years Adult: 19-44 years Female Male ab: Studies have demonstrated that episodic memory (EM) is often preferentially disrupted in schizophrenia. The neural substrates that mediate EM impairment in this illness are not fully understood. Several functional magnetic resonance imaging (fMRI) studies have employed EM probe tasks to elucidate the neural underpinnings of impairment, though results have been inconsistent. The majority of EM imaging studies have been conducted in chronic forms of schizophrenia with relatively few studies in early phase patients. Early phase schizophrenia studies are important because they may provide information regarding when EM deficits occur and address potential confounds more frequently observed in chronic populations. In this study, we assessed brain activation during the performance of visual scene encoding and recognition fMRI tasks in patients with earlyphase psychosis (n = 35) and age, sex, and race matched healthy control subjects (n = 20). Patients demonstrated significantly lower activation than controls in the right hippocampus and left fusiform gyrus during scene encoding and lower activation in the posterior cingulate, precuneus, and left middle temporal cortex during recognition of target scenes. Symptom levels were not related to the imaging findings, though better cognitive performance in patients was associated with greater right hippocampal activation during encoding. These results provide evidence of altered function in neuroanatomical circuitry subserving EM early in the course of psychotic illness, which may have implications for pathophysiological models of this illness. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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