A rare case of cerebellar agenesis: a probabilistic Constrained Spherical Deconvolution tractographic study.
Aim of this study is to show the potential of probabilistic tractographic techniques, based on the Constrained Spherical Deconvolution (CSD) algorithms, in recognizing white matter fiber bundle anomalies in patients with complex cerebral malformations, such as cerebellar agenesis. The morphological...
| Published in: | Brain Imaging & Behavior Vol. 10; no. 1; pp. 158 - 168 |
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| Main Authors: | , , , , , , , , , , , , , |
| Format: | case study research Journal Article |
| Published: |
Springer Nature
Mar2016
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=113546402&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 113546402 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Mar2016 vid: 10 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 113546402 113546402 NLM25832852 113546402 10.1007/s11682-015-9377-5 NLM25832852 113546402 ppf: 158 ppct: 10 formats: fmt: @attributes: type: P tig: atl: A rare case of cerebellar agenesis: a probabilistic Constrained Spherical Deconvolution tractographic study. aug: au: Mormina, Enricomaria Briguglio, Marilena Morabito, Rosa Arrigo, Alessandro Marino, Silvia Di Rosa, Gabriella Micalizzi, Alessia Valente, Enza Salpietro, Vincenzo Vinci, Sergio Longo, Marcello Granata, Francesca Valente, Enza Maria Vinci, Sergio Lucio affil: Neuroradiology Unit - Department of Biomedical Sciences and Morpho-Functional Imaging, University of Messina, via Consolare Valeria, 1 A.O.U. Policlinico 'G. Martino' 98125 Messina Italy sug: subj: Algorithms Image Processing, Computer Assisted Methods Cerebellum Cerebellum Abnormalities Magnetic Resonance Imaging Methods Neural Pathways Brain Stem Abnormalities Brain Neural Pathways Abnormalities Male Adolescence Brain Abnormalities Brain Stem Human Validation Studies Comparative Studies Evaluation Research Multicenter Studies Adolescent: 13-18 years Male ab: Aim of this study is to show the potential of probabilistic tractographic techniques, based on the Constrained Spherical Deconvolution (CSD) algorithms, in recognizing white matter fiber bundle anomalies in patients with complex cerebral malformations, such as cerebellar agenesis. The morphological and tractographic study of a 17-year-old male patient affected by cerebellar agenesis was performed by using a 3Tesla MRI scanner. Genetic and neuropsychological tests were carried out. An MRI morphological study showed the absence of both cerebellar hemispheres and the flattening of the anterior side of the pons. Moreover, it showed a severe vermian hypoplasia with a minimal vermian residual. The study recognized two thin cerebellar remnants, medially in contact with the small vermian residual, at the pontine level. The third ventricle, morphologically normal, communicated with a permagna cerebello-medullary cistern. Probabilistic CSD tractography identified some abnormal and aberrant infratentorial tracts, symmetrical on both sides. In particular, the transverse pontine fibers were absent and the following tracts with aberrant trajectories have been identified: "cerebello-thalamic" tracts; "fronto-cerebellar" tracts; and ipsilateral and contralateral "spino-cerebellar" tracts. Abnormal tracts connecting the two thin cerebellar remnants have also been detected. There were no visible alterations in the main supratentorial tracts in either side. Neuropsychiatric evaluation showed moderate cognitive-motor impairment with discrete adaptive compensation. Probabilistic CSD tractography is a promising technique that overcome reconstruction biases of other diffusion tensor-based approaches and allowed us to recognize, in a patient with cerebellar agenesis, abnormal tracts and aberrant trajectories of normally existing tracts. pubtype: Academic Journal doctype: case study research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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