Hypo-metabolism of the rostral anterior cingulate cortex associated with working memory impairment in 18 cases of schizophrenia.
Working memory (Work-Mem), the capacity to hold and manipulate information, activates the anterior cingulate cortex (ACC), especially its caudal subregion. Impaired Work-Mem and structural and functional abnormalities of the ACC are reported in schizophrenia. This study aims to elucidate the pathoge...
| Published in: | Brain Imaging & Behavior Vol. 10; no. 1; pp. 115 - 124 |
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| Main Authors: | , , , , , , , , |
| Format: | diagnostic images research tables/charts tracings Journal Article |
| Published: |
Springer Nature
Mar2016
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=113546406&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 113546406 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Mar2016 vid: 10 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 113546406 113546406 NLM25804309 113546406 10.1007/s11682-015-9372-x NLM25804309 PMC4583324 [Available on 03/01/17] 113546406 ppf: 115 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Hypo-metabolism of the rostral anterior cingulate cortex associated with working memory impairment in 18 cases of schizophrenia. aug: au: Mazgaj, Robert Tal, Assaf Goetz, Raymond Lazar, Mariana Rothman, Karen Messinger, Julie Malaspina, Dolores Gonen, Oded Messinger, Julie Walsh affil: Department of Radiology, New York University School of Medicine, 660 First Avenue New York 10016 USA sug: subj: Memory Disorders Metabolism Psychology Limbic System Metabolism Memory, Short Term Schizophrenia Metabolism Creatine Metabolism Reproduction Young Adult Male Pathologic Processes Metabolism Proton Magnetic Resonance Spectroscopy Aspartic Acid Analogs and Derivatives Inositol Metabolism Aging Schizophrenia Drug Therapy Neuropsychological Tests Adult Retrospective Design Intelligence Tests Female Middle Age Aspartic Acid Metabolism Scales Funding Source Human Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Working memory (Work-Mem), the capacity to hold and manipulate information, activates the anterior cingulate cortex (ACC), especially its caudal subregion. Impaired Work-Mem and structural and functional abnormalities of the ACC are reported in schizophrenia. This study aims to elucidate the pathogenesis of Work-Mem dysfunction in schizophrenia by comparing metabolite concentrations across ACC subregions. This retrospective study of 18 schizophrenia cases and 10 matched controls used proton magnetic resonance spectroscopic imaging ((1)H-MRSI, TR/TE = 1800/35 ms, 0.5 cm(3) spatial resolution) to test whether the Work-Mem Index of the Wechsler Adult Intelligence Scale, third edition is associated with differences in the rostral to caudal ACC ratios of N-acetylaspartate (NAA) and creatine (Cr). Higher caudal:rostral ACC Cr (but not NAA) concentrations were associated with decreased Work-Mem Index in cases (r = -0.6, p = 0.02), with a similar trend in controls (r = -0.56, p = 0.10), although caudal:rostral ACC Cr correlated with NAA in cases and controls (r = 0.67 and 0.62, p < 0.05 for both). NAA and Cr ratios did not correlate with myo-inositol, excluding gliosis as the underlying process. Subjects' sex and age had no effects on these relationships. The findings suggest that rostral ACC energy hypo-metabolism, possibly arising from neurodevelopmental processes, is associated with working memory impairment in schizophrenia. Changes in the rostral (not the expected caudal) subregion underscore the interconnections between the ACC subregions and may offer laboratory markers for treatment trials, etiology studies, and perhaps even enhanced identification of prodromal "at risk" subjects. pubtype: Academic Journal doctype: diagnostic images research tables/charts tracings Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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