Subcortical nuclei volumes in suicidal behavior: nucleus accumbens may modulate the lethality of acts.
Previously, studies have demonstrated cortical impairments in those who complete or attempt suicide. Subcortical nuclei have less often been implicated in the suicidal vulnerability. In the present study, we investigated, with a specific design in a large population, variations in the volume of subc...
| Publicado en: | Brain Imaging & Behavior Vol. 10; no. 1; pp. 96 - 105 |
|---|---|
| Autores principales: | , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Mar2016
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=113546408&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 113546408 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Mar2016 vid: 10 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 113546408 113546408 NLM25759286 113546408 10.1007/s11682-015-9369-5 NLM25759286 113546408 ppf: 96 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Subcortical nuclei volumes in suicidal behavior: nucleus accumbens may modulate the lethality of acts. aug: au: Gifuni, Anthony Ding, Yang Olié, Emilie Lawrence, Natalia Cyprien, Fabienne Le Bars, Emmanuelle Bonafé, Alain Phillips, Mary Courtet, Philippe Jollant, Fabrice Gifuni, Anthony J Olié, Emilie Bonafé, Alain Phillips, Mary L affil: McGill Group for Suicide Studies, McGill University and Douglas Mental Health University Institute, 6875 boulevard Lasalle Montréal H4H 1R3 Canada sug: subj: Affective Disorders Suicide, Attempted Basal Ganglia Adult Young Adult Psychotropic Drugs Therapeutic Use Basal Ganglia Pathology Adolescence Image Processing, Computer Assisted Body Weights and Measures Basal Ganglia Drug Effects Affective Disorders Pathology Affective Disorders Drug Therapy Human Middle Age Magnetic Resonance Imaging Methods Female Male Validation Studies Comparative Studies Evaluation Research Multicenter Studies Adult: 19-44 years Adolescent: 13-18 years Middle Aged: 45-64 years Female Male ab: Previously, studies have demonstrated cortical impairments in those who complete or attempt suicide. Subcortical nuclei have less often been implicated in the suicidal vulnerability. In the present study, we investigated, with a specific design in a large population, variations in the volume of subcortical structures in patients with mood disorders who have attempted suicide. We recruited 253 participants: 73 suicide attempters with a past history of both mood disorders and suicidal act, 89 patient controls with a past history of mood disorders but no history of suicidal act, and 91 healthy controls. We collected 1.5 T magnetic resonance imaging data from the caudate, pallidum, putamen, nucleus accumbens, hippocampus, amygdala, ventral diencephalon, and thalamus. Surface-based morphometry (Freesurfer) analysis was used to comprehensively evaluate gray matter volumes. In comparison to controls, suicide attempters showed no difference in subcortical volumes when controlled for intracranial volume. However, within attempters negative correlations between the left (r = -0.35, p = 0.002), and right (r = -0.41, p < 0.0005) nucleus accumbens volumes and the lethality of the last suicidal act were found. Our study found no differences in the volume of eight subcortical nuclei between suicide attempters and controls, suggesting a lack of association between these regions and suicidal behavior in general. However, individual variations in nucleus accumbens structure and functioning may modulate the lethality of suicidal acts during a suicidal crisis. The known role of nucleus accumbens in action selection toward goals determined by the prefrontal cortex, decision-making or mental pain processing are hypothesized to be potential explanations. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|