Phase angle and its determinants in healthy subjects: influence of body composition.
Background: The phase angle (PA) has been used as a prognostic marker in several clinical situations. Nevertheless, its biological meaning is not completely understood. Objective: We verified how body-composition components could explain the PA. Design: The trial was a cross-sectional study involvin...
| Publicado en: | American Journal of Clinical Nutrition Vol. 103; no. 3; pp. 712 - 717 |
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| Autores principales: | , , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Elsevier B.V.
3/1/2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=113555998&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 113555998 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00029165 AJC jtl: American Journal of Clinical Nutrition issn: 00029165 maglogo: N pubinfo: dt: 3/1/2016 vid: 103 iid: 3 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 113555998 113555998 113555998 10.3945/ajcn.115.116772 113555998 ppf: 712 ppct: 5 formats: tig: atl: Phase angle and its determinants in healthy subjects: influence of body composition. aug: au: Gonzalez, Maria Cristina Barbosa-Silva, Thiago G. Bielemann, Renata M. Gallagher, Dympna Heymsfield, Steven B. affil: Post-graduation Program on Health and Behavior, Catholic University of Pelotas, Pelotas, Brazil sug: subj: Phase Angle Body Composition Human Cross Sectional Studies Male Female Doubly Labeled Water Technique Potassium Analysis Body Water Analysis Absorptiometry, Photon Adipose Tissue Analysis Fat Free Mass Analysis Hydrodensitometry Electric Impedance Multivariate Analysis Linear Regression Sex Factors Age Factors Body Height Evaluation Mathematics New York Body Weight Evaluation Body Mass Index Evaluation Data Analysis Software Mann-Whitney U Test Effect Size P-Value Pearson's Correlation Coefficient Black Persons White Persons Asians Hispanic Americans Adult Middle Age Descriptive Statistics Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Background: The phase angle (PA) has been used as a prognostic marker in several clinical situations. Nevertheless, its biological meaning is not completely understood. Objective: We verified how body-composition components could explain the PA. Design: The trial was a cross-sectional study involving 1442 participants (women: 58.5%; Caucasian: 40.2%) from body-composition studies. Labeled tritium dilution and total-body potassium were used to estimate total-body water (TBW) and intracellular water (ICW), respectively. Extracellular water (ECW) and the ECW:ICW ratio were estimated from the difference and the ratio of these values. Fat-free mass (FFM) and fat mass (FM) were estimated with the use of dual-energy X-ray absorptiometry, underwater weighing (UWW), and TBW. The PA was estimated with the use of a single-frequency bioelectrical impedance analysis system. Correlations between the PA and all body-composition variables were evaluated. A multivariate linear regression analysis was performed to adjust for the effects of body-composition variables on the PA variability. All analyses were performed separately by sex. Results: Compared with men, women exhibited significantly larger ECW:ICW ratios and FM. The highest positive correlation was shown between the PA and FFM obtained with the use of UWW (both sexes). The highest negative correlation was shown between the PA and ECW: ICW ratios for both sexes. Age, race, height, ECW:ICW, and FFM from UWW were significant PA determinants in a multivariate linear regression model. Even after adjustment for all significant covariates, the explained PA variance was low (adjusted R² = 0.539 and 0.421 in men and women, respectively). The greatest impact on the total PA prediction in both men and women were age, FFM, and height. Conclusions: Age is the most significant PA predictor in men and women followed by FFM and height. The ECW:ICW contribution may explain the association of the PA observed in the clinical setting and in people who are obese. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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