Mechanistic Studies on the Use of Polygonum multiflorum for the Treatment of Hair Graying.
Polygonum multiflorum is a traditional Chinese medicine with a long history in hair growth promotion and hair blackening. The purpose of the study was to examine the effect and the mechanism of Polygonum multiflorum in hair blackening. C57BL/6 mice hair fade was induced with H2O2 and used in this re...
| Publicado en: | BioMed Research International Vol. 2015; pp. 1 - 9 |
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| Autores principales: | , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
11/10/2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=113630037&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 113630037 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 11/10/2015 vid: 2015 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 113630037 113630037 113630037 10.1155/2015/651048 113630037 ppf: 1 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Mechanistic Studies on the Use of Polygonum multiflorum for the Treatment of Hair Graying. aug: au: Han, Ming-Nuan Lu, Jian-Mei Zhang, Guang-Yuan Yu, Jie Zhao, Rong-Hua affil: Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan 650500, China sug: subj: Hair Medicine, Chinese Traditional Plants, Medicinal Administration and Dosage Color Aging Animal Studies Molecular Structure Mice Hydrogen Peroxide Administration and Dosage Pigmentation Cytokines Drug Effects Enzymes Drug Effects Chromatography, High Pressure Liquid Random Assignment Hair Analysis Descriptive Statistics One-Way Analysis of Variance Pearson's Correlation Coefficient P-Value Funding Source ab: Polygonum multiflorum is a traditional Chinese medicine with a long history in hair growth promotion and hair blackening. The purpose of the study was to examine the effect and the mechanism of Polygonum multiflorum in hair blackening. C57BL/6 mice hair fade was induced with H2O2 and used in this research. Hair pigmentogenesis promotion activities of Polygonum Multiflorum Radix (PMR, raw crude drug), Polygonum Multiflorum Radix Preparata (PMRP, processed crude drug), and their major chemical constituent TSG were investigated. The regulation effects of several cytokines and enzymes such as POMC, α-MSH, MC1R, ASIP, MITF, TYR, TRP-1, and TRP-2 were investigated. PMR group gave out the most outstanding black hair among all groups with the highest contents of total melanin, α-MSH, MC1R, and TYR. Promotion of hair pigmentogenesis was slightly decreased after processing in the PMRP group. TSG as the major constituent of PMR showed weaker hair color regulation effects than both PMR and PMRP. PMR, but not PMRP, should be used to blacken hair. The α-MSH, MC1R, and TYR were the major targets in the medicinal use of PMR in hair graying. Chemical constituents other than TSG may contribute to the hair color regulation activity of PMR. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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