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Source-Space Cross-Frequency Amplitude-Amplitude Coupling in Tinnitus.

The thalamocortical dysrhythmia (TCD) model has been influential in the development of theoretical explanations for the neurological mechanisms of tinnitus. It asserts that thalamocortical oscillations lock a region in the auditory cortex into an ectopic slow-wave theta rhythm (4–8 Hz). The cortical...

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Published in:BioMed Research International Vol. 2015; pp. 1 - 16
Main Authors: Zobay, Oliver, Adjamian, Peyman
Format: research tables/charts Journal Article
Published: Wiley-Blackwell 11/19/2015
Online Access:View this record in EBSCOhost
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      dt: 11/19/2015
      vid: 2015
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        10.1155/2015/489619
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        atl: Source-Space Cross-Frequency Amplitude-Amplitude Coupling in Tinnitus.
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          Zobay, Oliver
          Adjamian, Peyman
        affil: MRC Institute of Hearing Research, University Park, Nottingham NG7 2RD, UK
      sug:
        subj:
          Tinnitus Etiology
          Auditory Cortex Physiopathology
          Human
          Age Factors
          Electroencephalography
      ab: The thalamocortical dysrhythmia (TCD) model has been influential in the development of theoretical explanations for the neurological mechanisms of tinnitus. It asserts that thalamocortical oscillations lock a region in the auditory cortex into an ectopic slow-wave theta rhythm (4–8 Hz). The cortical area surrounding this region is hypothesized to generate abnormal gamma (>30 Hz) oscillations (“edge effect”) giving rise to the tinnitus percept. Consequently, the model predicts enhanced cross-frequency coherence in a broad range between theta and gamma. In this magnetoencephalography study involving tinnitus and control cohorts, we investigated this prediction. Using beamforming, cross-frequency amplitude-amplitude coupling (AAC) was computed within the auditory cortices for frequencies (f1,f2) between 2 and 80 Hz. We find the AAC signal to decompose into two distinct components at low (f1,f2<30 Hz) and high (f1,f2>30 Hz) frequencies, respectively. Studying the correlation of AAC with several key covariates (age, hearing level (HL), tinnitus handicap and duration, and HL at tinnitus frequency), we observe a statistically significant association between age and low-frequency AAC. Contrary to the TCD predictions, however, we do not find any indication of statistical differences in AAC between tinnitus and controls and thus no evidence for the predicted enhancement of cross-frequency coupling in tinnitus.
      pubtype: Academic Journal
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        Journal Article
      ougenre: Article
    language: English
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