Validation of Urine Test for Detection of Helicobacter pylori Infection in Indonesian Population.
We measured the accuracy of the urine test (RAPIRUN) for detection of Helicobacter pylori infection in Indonesia (Jakarta, Pontianak, and Jayapura) using histology confirmed by immunohistochemistry and/or culture as gold standards. We also used immunohistochemistry to identify CagA phenotype and ana...
| Publicado en: | BioMed Research International Vol. 2015; pp. 1 - 7 |
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| Autores principales: | , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
12/28/2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=113630246&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 113630246 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 12/28/2015 vid: 2015 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 113630246 113630246 113630246 10.1155/2015/152823 113630246 ppf: 1 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Validation of Urine Test for Detection of Helicobacter pylori Infection in Indonesian Population. aug: au: Syam, Ari Fahrial Miftahussurur, Muhammad Uwan, Willy Brodus Simanjuntak, David Uchida, Tomohisa Yamaoka, Yoshio affil: Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta 10430, Indonesia sug: subj: Helicobacter Infections Diagnosis Helicobacter Pylori Analysis Urinalysis Validity Human Indonesia Immunohistochemistry Helicobacter Pylori Classification Prevalence Helicobacter Infections Epidemiology Descriptive Statistics Sensitivity and Specificity Predictive Value of Tests Antibodies Prospective Studies Data Analysis Software Chi Square Test T-Tests Mann-Whitney U Test P-Value Adult Middle Age Male Female Genotype Funding Source Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: We measured the accuracy of the urine test (RAPIRUN) for detection of Helicobacter pylori infection in Indonesia (Jakarta, Pontianak, and Jayapura) using histology confirmed by immunohistochemistry and/or culture as gold standards. We also used immunohistochemistry to identify CagA phenotype and analyzed H. pylori CagA diversity in Indonesia. The overall prevalence of H. pylori infection in 88 consecutive dyspeptic patients based on the urine test was 15.9% (14/88), 38.1% for patients in Jayapura that had higher prevalence of H. pylori infection than that in Jakarta (9.7%, P=0.02) and Pontianak (8.3%, P=0.006). Overall sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of RAPIRUN were 83.3%, 94.7%, 71.4%, 97.3%, and 93.2%, respectively. All of the H. pylori-positive patients were immunoreactive for anti-CagA antibody but not immunoreactive for East Asian specific anti-CagA antibody in all H. pylori-positive subjects. We confirmed the high accuracy of RAPIRUN in Indonesian population. In general, we found less virulent type of H. pylori in Indonesia, which partly explained the low incidence gastric cancer in Indonesia. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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