Inhibition of DNA Topoisomerase Type IIα (TOP2A) by Mitoxantrone and Its Halogenated Derivatives: A Combined Density Functional and Molecular Docking Study.

In this study, mitoxantrone and its halogenated derivatives have been designed by density functional theory (DFT) to explore their structural and thermodynamical properties. The performance of these drugs was also evaluated to inhibit DNA topoisomerase type IIα (TOP2A) by molecular docking calculati...

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Bibliographic Details

Published in:	BioMed Research International Vol. 2016; pp. 1 - 13
Main Authors:	Abu Saleh, Md., Solayman, Md., Hoque, Mohammad Mazharol, Khan, Mohammad A. K., Sarwar, Mohammed G., Halim, Mohammad A.
Format:	pictorial research tables/charts Journal Article
Published:	Wiley-Blackwell 1/27/2016
Online Access:	View this record in EBSCOhost