Application of PK/PD Modeling in Veterinary Field: Dose Optimization and Drug Resistance Prediction.
Among veterinary drugs, antibiotics are frequently used. The true mean of antibiotic treatment is to administer dose of drug that will have enough high possibility of attaining the preferred curative effect, with adequately low chance of concentration associated toxicity. Rising of antibacterial res...
| Publicado en: | BioMed Research International Vol. 2016; pp. 1 - 13 |
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| Autores principales: | , , , , |
| Formato: | review Journal Article |
| Publicado: |
Wiley-Blackwell
2/16/2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=113630443&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 113630443 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 2/16/2016 vid: 2016 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 113630443 113630443 113630443 10.1155/2016/5465678 113630443 ppf: 1 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Application of PK/PD Modeling in Veterinary Field: Dose Optimization and Drug Resistance Prediction. aug: au: Ahmad, Ijaz Huang, Lingli Hao, Haihong Sanders, Pascal Yuan, Zonghui affil: National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei 430070, China sug: subj: Veterinary Medicine Antibiotics Administration and Dosage Drug Resistance, Microbial Dosage Calculation Antibiotics Pharmacodynamics Antibiotics Pharmacokinetics ab: Among veterinary drugs, antibiotics are frequently used. The true mean of antibiotic treatment is to administer dose of drug that will have enough high possibility of attaining the preferred curative effect, with adequately low chance of concentration associated toxicity. Rising of antibacterial resistance and lack of novel antibiotic is a global crisis; therefore there is an urgent need to overcome this problem. Inappropriate antibiotic selection, group treatment, and suboptimal dosing are mostly responsible for the mentioned problem. One approach to minimizing the antibacterial resistance is to optimize the dosage regimen. PK/PD model is important realm to be used for that purpose from several years. PK/PD model describes the relationship between drug potency, microorganism exposed to drug, and the effect observed. Proper use of the most modern PK/PD modeling approaches in veterinary medicine can optimize the dosage for patient, which in turn reduce toxicity and reduce the emergence of resistance. The aim of this review is to look at the existing state and application of PK/PD in veterinary medicine based on in vitro, in vivo, healthy, and disease model. pubtype: Academic Journal doctype: review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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