Interictal high-frequency oscillations in focal human epilepsy.
Purpose Of Review: Localization of focal epileptic brain is critical for successful epilepsy surgery and focal brain stimulation. Despite significant progress, roughly half of all patients undergoing focal surgical resection, and most patients receiving focal electrical stimulation, are not seizure...
| Publicado en: | Current Opinion in Neurology Vol. 29; no. 2; pp. 175 - 182 |
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| Autores principales: | , , |
| Formato: | research Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Apr2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=113731629&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 113731629 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13507540 IM9 jtl: Current Opinion in Neurology issn: 13507540 maglogo: N pubinfo: dt: Apr2016 vid: 29 iid: 2 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 113731629 113731629 NLM26953850 113731629 10.1097/WCO.0000000000000302 NLM26953850 PMC4941960 113731629 ppf: 175 ppct: 7 formats: tig: atl: Interictal high-frequency oscillations in focal human epilepsy. aug: au: Cimbalnik, Jan Kucewicz, Michal T. Worrell, Greg affil: Mayo Systems Electrophysiology Laboratory, Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA sug: subj: Epilepsy, Partial Physiopathology Brain Mapping Electric Stimulation Methods Brain Physiopathology Electroencephalography Methods Epilepsy, Partial Diagnosis Human Validation Studies Comparative Studies Evaluation Research Multicenter Studies Funding Source ab: Purpose Of Review: Localization of focal epileptic brain is critical for successful epilepsy surgery and focal brain stimulation. Despite significant progress, roughly half of all patients undergoing focal surgical resection, and most patients receiving focal electrical stimulation, are not seizure free. There is intense interest in high-frequency oscillations (HFOs) recorded with intracranial electroencephalography as potential biomarkers to improve epileptogenic brain localization, resective surgery, and focal electrical stimulation. The present review examines the evidence that HFOs are clinically useful biomarkers.Recent Findings: Performing the PubMed search 'High-Frequency Oscillations and Epilepsy' for 2013-2015 identifies 308 articles exploring HFO characteristics, physiological significance, and potential clinical applications.Summary: There is strong evidence that HFOs are spatially associated with epileptic brain. There remain, however, significant challenges for clinical translation of HFOs as epileptogenic brain biomarkers: Differentiating true HFO from the high-frequency power changes associated with increased neuronal firing and bandpass filtering sharp transients. Distinguishing pathological HFO from normal physiological HFO. Classifying tissue under individual electrodes as normal or pathological. Sharing data and algorithms so research results can be reproduced across laboratories. Multicenter prospective trials to provide definitive evidence of clinical utility. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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