Risk of chemotherapy-induced febrile neutropenia in cancer patients receiving pegfilgrastim prophylaxis: does timing of administration matter?
Purpose: Contrary to the approved indication for pegfilgrastim prophylaxis, some patients receive it on the same day as the last administration of chemotherapy in clinical practice, which could adversely impact risk of febrile neutropenia (FN). An evaluation of the timing of pegfilgrastim prophylaxi...
| Publicado en: | Supportive Care in Cancer Vol. 24; no. 5; pp. 2309 - 2317 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
May2016
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=113946199&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 113946199 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09414355 O1J jtl: Supportive Care in Cancer issn: 09414355 maglogo: N pubinfo: dt: May2016 vid: 24 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 113946199 113946199 NLM26607482 113946199 10.1007/s00520-015-3036-7 NLM26607482 PMC4805705 113946199 ppf: 2309 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Risk of chemotherapy-induced febrile neutropenia in cancer patients receiving pegfilgrastim prophylaxis: does timing of administration matter? aug: au: Weycker, Derek Li, Xiaoyan Figueredo, Jacqueline Barron, Rich Tzivelekis, Spiros Hagiwara, May affil: Policy Analysis Inc. (PAI), Four Davis Court Brookline 02445 USA sug: subj: Lymphoma, Non-Hodgkin's Drug Therapy Granulocyte Colony-Stimulating Factor Metabolism Neutropenia Etiology Recombinant Proteins Adverse Effects Granulocyte Colony-Stimulating Factor Adverse Effects Retrospective Design Human Recombinant Proteins Administration and Dosage Granulocyte Colony-Stimulating Factor Administration and Dosage Male Middle Age Female Prospective Studies Granulocyte Colony-Stimulating Factor Therapeutic Use Recombinant Proteins Therapeutic Use Validation Studies Comparative Studies Evaluation Research Multicenter Studies Middle Aged: 45-64 years Male Female ab: Purpose: Contrary to the approved indication for pegfilgrastim prophylaxis, some patients receive it on the same day as the last administration of chemotherapy in clinical practice, which could adversely impact risk of febrile neutropenia (FN). An evaluation of the timing of pegfilgrastim prophylaxis and FN risk was undertaken.Methods: A retrospective cohort design and data from two US private health care claims repositories were employed. Study population comprised adults who received intermediate/high-risk chemotherapy regimens for solid tumors or non-Hodgkin's lymphoma (NHL) and received pegfilgrastim prophylaxis in ≥1 cycle; all cycles with pegfilgrastim were pooled for analyses. Odds ratios (OR) for FN during the cycle were estimated for patients who received pegfilgrastim on the same day (day 1) as the last administration of chemotherapy versus days 2-4 from chemotherapy completion.Results: The study population included 45,592 patients who received pegfilgrastim in 179,152 cycles (n = 37,095 in cycle 1); in 12 % of cycles, patients received pegfilgrastim on the same day as chemotherapy. Odds of FN were higher for patients receiving pegfilgrastim prophylaxis on the same day as chemotherapy versus days 2-4 from chemotherapy in cycle 1 (OR = 1.6, 95 % CI = 1.3-1.9, p < 0.001) and all cycles (OR = 1.5, 95 % CI = 1.3-1.6, p < 0.001).Conclusions: In this large-scale evaluation of adults who received intermediate/high-risk regimens for solid tumors or NHL in US clinical practice, FN incidence was found to be significantly higher among those who received pegfilgrastim prophylaxis on the same day as chemotherapy completion versus days 2-4 from chemotherapy completion, underscoring the importance of adhering to the indicated administration schedule. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|