Cover Image
QR Code

Facile and cost-effective production of microscale PDMS architectures using a combined micromilling-replica moulding (μMi-REM) technique.

We describe a cost-effective and simple method to fabricate PDMS-based microfluidic devices by combining micromilling with replica moulding technology. It relies on the following steps: (i) microchannels are milled in a block of acrylic; (ii) low-cost epoxy adhesive resin is poured over the milled a...

Full description

Published in:Biomedical Microdevices Vol. 18; no. 1; pp. 4 - 14
Main Authors: Carugo, Dario, Jeong Yu Lee, Pora, Anne, Browning, Richard J., Capretto, Lorenzo, Nastruzzi, Claudio, Stride, Eleanor
Format: Journal Article
Published: Springer Nature Feb2016
Online Access:View this record in EBSCOhost
fields @attributes:
  recordID: 1
pdfLink:
plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=114082943&site=ehost-live
header:
  @attributes:
    shortDbName: ccm
    uiTerm: 114082943
    longDbName: CINAHL Complete
    uiTag: AN
  controlInfo:
    bkinfo:
    dissinfo:
    jinfo:
      jid:
        13872176
        ODN
      jtl: Biomedical Microdevices
      issn: 13872176
      maglogo: N
    pubinfo:
      dt: Feb2016
      vid: 18
      iid: 1
      pid: 237
      pub: Springer Nature
      place: New York, New York
    artinfo:
      ui:
        114082943
        10.1007/s10544-015-0027-x
        114082943
      ppf: 4
      ppct: 10
      formats:
        fmt:
          @attributes:
            type: P
      tig:
        atl: Facile and cost-effective production of microscale PDMS architectures using a combined micromilling-replica moulding (μMi-REM) technique.
      aug:
        au:
          Carugo, Dario
          Jeong Yu Lee
          Pora, Anne
          Browning, Richard J.
          Capretto, Lorenzo
          Nastruzzi, Claudio
          Stride, Eleanor
        affil: BUBBL, Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.
      sug:
      ab: We describe a cost-effective and simple method to fabricate PDMS-based microfluidic devices by combining micromilling with replica moulding technology. It relies on the following steps: (i) microchannels are milled in a block of acrylic; (ii) low-cost epoxy adhesive resin is poured over the milled acrylic block and allowed to cure; (iii) the solidified resin layer is peeled off the acrylic block and used as a mould for transferring the microchannel architecture onto a PDMS layer; finally (iv) the PDMS layer is plasma bonded to a glass surface. With this method, microscale architectures can be fabricated without the need for advanced technological equipment or laborious and time-consuming intermediate procedures. In this manuscript, we describe and validate the microfabrication procedure, and we illustrate its applicability to emulsion and microbubble production.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
    refInfo:
    holdings:
      @attributes:
        islocal: N