Urinary 3-(3-Hydroxyphenyl)-3-hydroxypropionic Acid, 3-Hydroxyphenylacetic Acid, and 3-Hydroxyhippuric Acid Are Elevated in Children with Autism Spectrum Disorders.
Autism spectrum disorders (ASDs) are a group of mental illnesses highly correlated with gut microbiota. Recent studies have shown that some abnormal aromatic metabolites in autism patients are presumably derived from overgrown Clostridium species in gut, which may be used for diagnostic purposes. In...
| Publicado en: | BioMed Research International Vol. 2016; pp. 1 - 9 |
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| Autores principales: | , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
3/30/2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=114108137&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 114108137 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 3/30/2016 vid: 2016 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 114108137 114108137 114108137 10.1155/2016/9485412 114108137 ppf: 1 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Urinary 3-(3-Hydroxyphenyl)-3-hydroxypropionic Acid, 3-Hydroxyphenylacetic Acid, and 3-Hydroxyhippuric Acid Are Elevated in Children with Autism Spectrum Disorders. aug: au: Xiong, Xiyue Liu, Dan Wang, Yichao Zeng, Ting Peng, Ying affil: Maternal and Child Health Care Hospital of Hunan Province, Changsha 410008, China sug: subj: Autism Spectrum Disorder Classification Lactic Acid Urine Acids, Carbocyclic Urine Carboxylic Acids Urine Human Descriptive Statistics Molecular Structure Gas Chromatography-Mass Spectrometry Microbiota P-Value Biological Markers Urine Vancomycin Administration and Dosage China Infant Child, Preschool Child Clostridium ROC Curve Regression Prospective Studies Male Female Data Analysis Software Factor Analysis Checklists Paired T-Tests Pearson's Correlation Coefficient Lactic Acid Metabolism Acids, Carbocyclic Metabolism Carboxylic Acids Metabolism Predictive Value of Tests Funding Source Infant: 1-23 months Child, Preschool: 2-5 years Child: 6-12 years Male Female ab: Autism spectrum disorders (ASDs) are a group of mental illnesses highly correlated with gut microbiota. Recent studies have shown that some abnormal aromatic metabolites in autism patients are presumably derived from overgrown Clostridium species in gut, which may be used for diagnostic purposes. In this paper, a GC/MS based metabolomic approach was utilized to seek similar biomarkers by analyzing the urinary information in 62 ASDs patients compared with 62 non-ASDs controls in China, aged 1.5–7. Three compounds identified as 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA), 3-hydroxyphenylacetic acid (3HPA), and 3-hydroxyhippuric acid (3HHA) were found in higher concentrations in autistic children than in the controls (p<0.001). After oral vancomycin treatment, urinary excretion of HPHPA (p<0.001), 3HPA (p<0.005), and 3HHA (p<0.001) decreased markedly, which indicated that these compounds may also be from gut Clostridium species. The sensitivity and specificity of HPHPA, 3HPA, and 3HHA were evaluated by receiver-operating characteristic (ROC) analysis. The specificity of each compound for ASDs was very high (>96%). After two-regression analysis, the optimal area under the curve (AUC, 0.962), sensitivity (90.3%), and specificity (98.4%) were obtained by ROC curve of Prediction probability based on the three metabolites. These findings demonstrate that the measurements of the three compounds are strong predictors of ASDs and support the potential clinical utility for identifying a subgroup of ASDs subjects. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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