Association between obesity and glomerular hyperfiltration: the confounding effect of smoking and sodium and protein intakes.
Purpose: Glomerular hyperfiltration has been suggested as a possible mechanism linking obesity and chronic kidney disease (CKD), independently of classical risk factors. We explored the association of overweight and obesity with glomerular hyperfiltration in a large sample of the Swiss adult populat...
| Publicado en: | European Journal of Nutrition Vol. 55; no. 3; pp. 1089 - 1098 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=114190399&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 114190399 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Apr2016 vid: 55 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 114190399 114190399 114190399 10.1007/s00394-015-0923-0 114190399 ppf: 1089 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Association between obesity and glomerular hyperfiltration: the confounding effect of smoking and sodium and protein intakes. aug: au: Ogna, Adam Forni Ogna, Valentina Bochud, Murielle Guessous, Idris Paccaud, Fred Burnier, Michel Wuerzner, Gregoire affil: Department of Internal Medicine and Nephrology, Locarno Hospital, 6600 Locarno Switzerland sug: subj: Obesity Glomerular Filtration Rate Human Switzerland Funding Source Nutritional Assessment Cross Sectional Studies Epidemiological Research Creatinine Urine Body Mass Index Evaluation Adult Middle Age Male Female Descriptive Statistics P-Value Confidence Intervals Odds Ratio Health Status Evaluation Life Style Evaluation Kidney Failure, Chronic Risk Factors Survey Research Sodium Urine Data Analysis Software T-Tests Chi Square Test Nonparametric Statistics Multiple Logistic Regression Aged Questionnaires Creatinine Blood Smoking Evaluation Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Purpose: Glomerular hyperfiltration has been suggested as a possible mechanism linking obesity and chronic kidney disease (CKD), independently of classical risk factors. We explored the association of overweight and obesity with glomerular hyperfiltration in a large sample of the Swiss adult population, accounting for several confounders including dietary factors. Methods: Data from a 2010 to 2012 cross-sectional population-based survey in Switzerland were used. Creatinine clearance (CrCl) was determined from 24-h urine collection; CrCl > 140 ml/min was used to define glomerular hyperfiltration. Participants were categorized into lean (<25 kg/m), overweight (25-29.9 kg/m) and obese (≥30 kg/m) according to body mass index (BMI). Results: A total of 1339 participants were included in the analysis [median (IQR) age 49.4 (34.3-63.5) years, 48.9 % men]. The prevalences of overweight and obesity were 32.2 and 14.2 %, respectively. Median CrCl was 102[84-121] ml/min in lean, 110 [87-136] ml/min in overweight and 124 [97-150] ml/min in obese participants ( p < 0.001). The prevalence of glomerular hyperfiltration increased across BMI categories (10.4, 20.8 and 34.7 %, respectively; p < 0.001). This positive association remained significant after adjusting for age, sex, hypertension, diabetes, smoking and dietary factors (sodium and protein intakes): odds ratio [95 %CI] 2.39 [1.52-3.76] ( p < 0.001) for overweight versus lean and 4.10[2.31-7.27] ( p < 0.001) for obesity versus lean. Conclusions: BMI categories and glomerular hyperfiltration are positively associated, independently of other known CKD risk factors and dietary confounders, suggesting that glomerular hyperfiltration may represent an early renal phenotype in obesity. Our observations confirm the significant association of glomerular hyperfiltration with sodium and protein intakes and identify sodium intake as an important modifying factor of the association between hyperfiltration and obesity. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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