UTX in muscle regeneration--the right dose and the right time.
Precise epigenetic modifications in stem cells control developmental programs and cell fate decisions. In particular, the addition or removal of trimethylation of histone 3 lysine 27 (H3K27me3) at lineage-specific genes has been linked to the repression of gene expression, and a precise balance of m...
| Publicado en: | Journal of Clinical Investigation Vol. 126; no. 4; pp. 1233 - 1236 |
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| Autores principales: | , , |
| Formato: | commentary tables/charts Journal Article |
| Publicado: |
American Society for Clinical Investigation
Apr2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=114199717&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 114199717 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00219738 0YX jtl: Journal of Clinical Investigation issn: 00219738 maglogo: N pubinfo: dt: Apr2016 vid: 126 iid: 4 pid: 11983 pub: American Society for Clinical Investigation place: Ann Arbor, Michigan artinfo: ui: 114199717 114199717 NLM26999609 114199717 10.1172/JCI86798 NLM26999609 PMC4811162 [Available on 04/01/17] 114199717 ppf: 1233 ppct: 3 formats: tig: atl: UTX in muscle regeneration--the right dose and the right time. aug: au: Ling Liu Rando, Thomas A. Liu, Ling affil: Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, California, USA sug: subj: Muscle Proteins Metabolism Muscle Fibers Physiology Stem Cells Genes Physiology Oxidoreductases Regeneration Physiology Male Animals Female Funding Source Male Female ab: Precise epigenetic modifications in stem cells control developmental programs and cell fate decisions. In particular, the addition or removal of trimethylation of histone 3 lysine 27 (H3K27me3) at lineage-specific genes has been linked to the repression of gene expression, and a precise balance of methyltransferases and demethylases within cells determines H3K27me3 levels. The demethylase UTX is essential for development and tissue homeostasis; however, a role for UTX in stem cell-mediated tissue regeneration is unknown. In this issue of the JCI, Dilworth and colleagues reveal that UTX and its demethylase activity are required in the muscle stem cell lineage for muscle regeneration in response to injury. Specifically, UTX mediates the removal of H3K27me3 in the promoter of the transcription factor myogenin, which regulates myogenic differentiation. The results of this study provide important insight into the contribution of epigenetic regulation in stem cell-mediated regeneration of adult tissues. pubtype: Academic Journal doctype: commentary tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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