Temporal lobe connects regression and macrocephaly to autism spectrum disorders.
Interictal electroencephalogram (EEG) abnormalities are frequently associated with autism spectrum disorders (ASD), although their relationship with the clinical features of ASD, particularly the regressive onset, remains controversial. The aim of this study was to investigate whether the characteri...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 25; no. 4; pp. 421 - 430 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | diagnostic images research tables/charts tracings Journal Article |
| Publicado: |
Springer Nature
Apr2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=114245384&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 114245384 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Apr2016 vid: 25 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 114245384 114245384 114245384 10.1007/s00787-015-0746-9 114245384 ppf: 421 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Temporal lobe connects regression and macrocephaly to autism spectrum disorders. aug: au: Valvo, Giulia Baldini, Sara Retico, Alessandra Rossi, Giuseppe Tancredi, Raffaella Ferrari, Anna Calderoni, Sara Apicella, Fabio Muratori, Filippo Santorelli, Filippo Sicca, Federico affil: Department of Developmental Neuroscience, IRCCS Stella Maris Foundation, Via dei Giacinti 2 - Calambrone 56128 Pisa Italy sug: subj: Autism Spectrum Disorder Temporal Lobe Regression (Psychology) Human Electroencephalography Chi Square Test Pearson's Correlation Coefficient Male Female Child, Preschool Child Adolescence Adult Descriptive Statistics Data Analysis Software T-Tests Magnetic Resonance Imaging Funding Source Child, Preschool: 2-5 years Child: 6-12 years Adolescent: 13-18 years Adult: 19-44 years Male Female ab: Interictal electroencephalogram (EEG) abnormalities are frequently associated with autism spectrum disorders (ASD), although their relationship with the clinical features of ASD, particularly the regressive onset, remains controversial. The aim of this study was to investigate whether the characteristics of interictal EEG abnormalities might help to distinguish and predict definite phenotypes within the heterogeneity of ASD. We reviewed the awake and sleep interictal EEGs of 220 individuals with idiopathic ASD, either with or without a history of seizures. EEG findings were analyzed with respect to a set of clinical variables to explore significant associations. A brain morphometry study was also carried out on a subgroup of patients. EEG abnormalities were seen in 154/220 individuals (70 %) and were mostly focal ( p < 0.01) with an anterior localization ( p < 0.001). They were detected more frequently during sleep ( p < 0.01), and were associated with a regressive onset of ASD ( p < 0.05), particularly in individuals with focal temporal localization ( p < 0.05). This association was also stronger in regressive patients with concurrent macrocephaly, together with a relative volumetric reduction of the right temporal cortex ( p < 0.05). Indeed, concurrence of temporal EEG abnormalities, regression and macrocephaly might possibly define a distinct endophenotype of ASD. EEG-based endophenotypes could be useful to untangle the complexity of ASD, helping to establish anatomic or pathophysiologic subtypes of the disorder. pubtype: Academic Journal doctype: diagnostic images research tables/charts tracings Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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