Automatic Tissue Differentiation Based on Confocal Endomicroscopic Images for Intraoperative Guidance in Neurosurgery.
Diagnosis of tumor and definition of tumor borders intraoperatively using fast histopathology is often not sufficiently informative primarily due to tissue architecture alteration during sample preparation step. Confocal laser microscopy (CLE) provides microscopic information of tissue in real-time...
| Publicado en: | BioMed Research International Vol. 2016; pp. 1 - 9 |
|---|---|
| Autores principales: | , , , , , , , , , , , |
| Formato: | equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
4/5/2016
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=114260964&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 114260964 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 4/5/2016 vid: 2016 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 114260964 114260964 114260964 10.1155/2016/6183218 114260964 ppf: 1 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Automatic Tissue Differentiation Based on Confocal Endomicroscopic Images for Intraoperative Guidance in Neurosurgery. aug: au: Kamen, Ali Sun, Shanhui Wan, Shaohua Kluckner, Stefan Chen, Terrence Gigler, Alexander M. Simon, Elfriede Fleischer, Maximilian Javed, Mehreen Daali, Samira Igressa, Alhadi Charalampaki, Patra affil: Siemens Healthcare, Technology Center, Princeton, NJ 08540, USA sug: subj: Microscopy Methods Neurosurgery Intraoperative Monitoring Tissue Analysis Brain Neoplasms Diagnosis Automation Brain Neoplasms Classification Human Algorithms Glioma Diagnosis Glioma Classification Meningioma Diagnosis Meningioma Classification Validity Tissue Culture Techniques Sensitivity and Specificity Funding Source Descriptive Statistics Germany ab: Diagnosis of tumor and definition of tumor borders intraoperatively using fast histopathology is often not sufficiently informative primarily due to tissue architecture alteration during sample preparation step. Confocal laser microscopy (CLE) provides microscopic information of tissue in real-time on cellular and subcellular levels, where tissue characterization is possible. One major challenge is to categorize these images reliably during the surgery as quickly as possible. To address this, we propose an automated tissue differentiation algorithm based on the machine learning concept. During a training phase, a large number of image frames with known tissue types are analyzed and the most discriminant image-based signatures for various tissue types are identified. During the procedure, the algorithm uses the learnt image features to assign a proper tissue type to the acquired image frame. We have verified this method on the example of two types of brain tumors: glioblastoma and meningioma. The algorithm was trained using 117 image sequences containing over 27 thousand images captured from more than 20 patients. We achieved an average cross validation accuracy of better than 83%. We believe this algorithm could be a useful component to an intraoperative pathology system for guiding the resection procedure based on cellular level information. pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|