Impaired Gas Exchange at Birth and Risk of Intellectual Disability and Autism: A Meta-analysis.
We conducted meta-analyses of 67 studies on the association between neonatal proxies of impaired gas exchange and intellectual disability (ID) or autism spectrum disorders (ASD). Neonatal acidosis was associated with an odds ratio (OR) of 3.55 [95 % confidence interval (95 % CI) 2.23-5.49] for ID an...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 46; no. 5; pp. 1847 - 1860 |
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| Autores principales: | , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Springer Nature
May2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=114435795&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 114435795 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: May2016 vid: 46 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 114435795 114435795 114435795 10.1007/s10803-016-2717-5 114435795 ppf: 1847 ppct: 13 formats: fmt: @attributes: type: P tig: atl: Impaired Gas Exchange at Birth and Risk of Intellectual Disability and Autism: A Meta-analysis. aug: au: Modabbernia, Amirhossein Mollon, Josephine Boffetta, Paolo Reichenberg, Abraham sug: subj: Intellectual Disability Risk Factors Autism Spectrum Disorder Risk Factors Anoxia Pulmonary Gas Exchange Systematic Review Meta Analysis Data Analysis Software Odds Ratio Confidence Intervals Medline Apgar Score Regression Bias (Research) Sensitivity and Specificity P-Value Acidosis Funding Source Asphyxia Neonatorum Human Intelligence Infant, Newborn Chi Square Test Infant, Newborn: birth-1 month ab: We conducted meta-analyses of 67 studies on the association between neonatal proxies of impaired gas exchange and intellectual disability (ID) or autism spectrum disorders (ASD). Neonatal acidosis was associated with an odds ratio (OR) of 3.55 [95 % confidence interval (95 % CI) 2.23-5.49] for ID and an OR of 1.10 (95 % CI 0.91-1.31) for ASD. Children with a 5-min Apgar score of <7 had an OR of 5.39 (95 % CI 3.84-7.55) for ID and an OR of 1.67 (95 % CI 1.34-2.09) for ASD. O2 treatment was associated with an OR of 4.32 (95 % CI 3.23-5.78) for ID and an OR of 2.02 (95 % CI 1.45 to 2.83) for ASD. Our meta-analysis demonstrates an increased risk of ID and (to a lesser extent) ASD in children with neonatal hypoxia. Moreover, our findings raise the possibility that concomitant ID might account for the observed association between the gas exchange proxies and ASD. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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