Mapping chronic liver disease questionnaire scores onto SF-6D utility values in patients with primary sclerosing cholangitis.
Purpose: The chronic liver disease questionnaire (CLDQ) is a frequently used liver-specific quality of life instrument, but it does not provide information on preference-adjusted health status, which is essential for cost-utility analysis. We aimed to develop a mapping function deriving utilities fr...
| Publicado en: | Quality of Life Research Vol. 25; no. 4; pp. 947 - 958 |
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| Autores principales: | , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Apr2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=114514189&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 114514189 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09629343 GPQ jtl: Quality of Life Research issn: 09629343 maglogo: N pubinfo: dt: Apr2016 vid: 25 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 114514189 114514189 NLM26471264 114514189 10.1007/s11136-015-1161-x NLM26471264 114514189 ppf: 947 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Mapping chronic liver disease questionnaire scores onto SF-6D utility values in patients with primary sclerosing cholangitis. aug: au: Kalaitzakis, Evangelos Benito de Valle, Maria Rahman, Monira Lindkvist, Björn Björnsson, Einar Chapman, Roger Kontodimopoulos, Nick Lindkvist, Björn Björnsson, Einar affil: Institute of Internal Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg Sweden sug: subj: Health Status Liver Diseases Psychosocial Factors Algorithms Cholangitis, Sclerosing Psychosocial Factors Quality of Life Psychosocial Factors Middle Age Male Human Regression Liver Transplantation Cost Benefit Analysis Prospective Studies Cholangitis, Sclerosing Surgery Models, Theoretical Liver Diseases Surgery Female Validation Studies Comparative Studies Evaluation Research Multicenter Studies Short Form-36 Health Survey (SF-36) Questionnaires Middle Aged: 45-64 years Male Female ab: Purpose: The chronic liver disease questionnaire (CLDQ) is a frequently used liver-specific quality of life instrument, but it does not provide information on preference-adjusted health status, which is essential for cost-utility analysis. We aimed to develop a mapping function deriving utilities from the CLDQ in primary sclerosing cholangitis (PSC).Methods: Short form-6D (SF-6D) utilities were calculated from SF-36 data collected in a recent prospective study in which unselected patients with PSC also completed the CLDQ. Ordinary least squares (OLS), generalized linear, median, and kernel regression analyses were employed to devise a mapping function predicting utilities. This was validated in three random subsamples of the cohort and in a separate sample of PSC patients following liver transplantation. Adjusted R (2) and root-mean-square error (RMSE) as well as Pearson's r coefficients and mean absolute errors between predicted and observed values were used to determine model performance.Results: Decompensated liver disease and fatigue, systemic symptoms, and emotional distress, assessed with the CLDQ, were related to worse SF-6D utilities. The final OLS prediction model explained 66.3 % of the variance in the derivation sample. Predicted and observed utilities were strongly correlated (r = 0.807, p < 0.001), but the mean absolute error (0.0604) and adjusted RMSE (10.6 %) were of intermediate size. Similar model characteristics were observed after employment of generalized linear and median regression models and at validation.Conclusions: A model has been constructed, showing good validity predicting SF-6D utilities from CLDQ scores at the group level in PSC. Further testing is required to externally validate the model. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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