Predictive models to estimate utility from clinical questionnaires in schizophrenia: findings from EuroSC.
Objective: The clinical symptoms of schizophrenia are associated with serious social, quality of life and functioning alterations. Typically, data on health utilities are not available in clinical studies in schizophrenia. This makes the economic evaluation of schizophrenia treatments challenging. T...
| Publicado en: | Quality of Life Research Vol. 25; no. 4; pp. 925 - 935 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Apr2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=114514208&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 114514208 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09629343 GPQ jtl: Quality of Life Research issn: 09629343 maglogo: N pubinfo: dt: Apr2016 vid: 25 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 114514208 114514208 NLM26385367 114514208 10.1007/s11136-015-1120-6 NLM26385367 PMC4830865 114514208 ppf: 925 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Predictive models to estimate utility from clinical questionnaires in schizophrenia: findings from EuroSC. aug: au: Siani, Carole Peretti, Christian Millier, Aurélie Boyer, Laurent Toumi, Mondher de Peretti, Christian Millier, Aurélie affil: Research Laboratory in Knowledge Engineering (ERIC, EA3083), Institute of Pharmaceutical and Biological Sciences (ISPB), University Claude Bernard Lyon 1, 11 Rue Guillaume Paradin 69372 Lyon Cedex 08 France sug: subj: Models, Theoretical Depression Diagnosis Quality of Life Psychosocial Factors Antipsychotic Agents Therapeutic Use Schizophrenia Drug Therapy Human Adult Male Prospective Studies Adolescence Middle Age Female Young Adult France Linear Regression Germany Treatment Outcomes Aged Validation Studies Comparative Studies Evaluation Research Multicenter Studies Scales Questionnaires Adult: 19-44 years Adolescent: 13-18 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Objective: The clinical symptoms of schizophrenia are associated with serious social, quality of life and functioning alterations. Typically, data on health utilities are not available in clinical studies in schizophrenia. This makes the economic evaluation of schizophrenia treatments challenging. The purpose of this article was to provide a mapping function to predict unobserved utility values in patients with schizophrenia from the available clinical and socio-demographic information.Methods: The analysis was performed using data from EuroSC, a 2-year, multi-centre, cohort study conducted in France (N = 288), Germany (N = 618), and the UK (N = 302), totalling 1208 patients. Utility was calculated based on the EQ-5D questionnaire. The relationships between the utility values and the patients' socio-demographic and clinical characteristics (Positive and Negative Syndrome Scale--PANSS, Calgary Depression Scale for Schizophrenia--CDSS, Global Assessment of Functioning--GAF, extra-pyramidal symptoms measured by Barnes Akathisia Scale-BAS, age, sex, country, antipsychotic type) were modelled using a random and a fixed individual effects panel linear model.Results: The analysis demonstrated the prediction ability of the used parameters for estimating utility measures in patients with schizophrenia. Although there are small variations between countries, the same variables appear to be the key predictors. From a clinical perspective, age, gender, psychopathology, and depression were the most important predictors associated with the EQ-5D.Conclusion: This paper proposed a reliable, robust and easy-to-apply mapping method to estimate EQ-5D utilities based on demographic and clinical measures in schizophrenia. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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