The Diagnostic Accuracy of Incisional Biopsy in the Oral Cavity.
Purpose: To determine the accuracy of incisional biopsy examination to diagnose oral lesions.Materials and Methods: This retrospective cohort study was performed to determine the concordance rate between incisional biopsy examination and definitive resection diagnosis for different oral lesions. The...
| Publicado en: | Journal of Oral & Maxillofacial Surgery (02782391) Vol. 74; no. 5; pp. 959 - 965 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
W B Saunders
May2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=114522643&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 114522643 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02782391 1YP jtl: Journal of Oral & Maxillofacial Surgery (02782391) issn: 02782391 maglogo: N pubinfo: dt: May2016 vid: 74 iid: 5 pid: 1351 pub: W B Saunders place: Philadelphia, Pennsylvania artinfo: ui: 114522643 114522643 NLM26682520 114522643 10.1016/j.joms.2015.11.006 NLM26682520 114522643 ppf: 959 ppct: 6 formats: tig: atl: The Diagnostic Accuracy of Incisional Biopsy in the Oral Cavity. aug: au: Chen, Sara Forman, Michael Sadow, Peter M. August, Meredith affil: Resident PGY1, Department of Restorative Dentistry (Prosthodontics), University of Illinois at Chicago, Chicago, IL; Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA sug: subj: Biopsy Methods Mouth Diseases Diagnosis Mouth Pathology Adult Mouth Mucosa Pathology Retrospective Design Salivary Gland Diseases Pathology Mouth Diseases Pathology Child Salivary Gland Diseases Diagnosis Mouth Neoplasms Pathology Aged Female Aged, 80 and Over Male Mouth Surgery Young Adult Middle Age Adolescence Mouth Neoplasms Diagnosis Salivary Glands Pathology Human Adult: 19-44 years Child: 6-12 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Adolescent: 13-18 years Female Male ab: Purpose: To determine the accuracy of incisional biopsy examination to diagnose oral lesions.Materials and Methods: This retrospective cohort study was performed to determine the concordance rate between incisional biopsy examination and definitive resection diagnosis for different oral lesions. The study sample was derived from the population of patients who presented to the Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital (Boston, MA) from January 2005 through December 2012. Inclusion criteria were the diagnosis of an oral lesion from an incisional biopsy examination, subsequent diagnosis from the definitive resection of the same lesion, and complete clinical and pathologic patient records. The predictor variables were the origin and size of the lesion. The primary outcome variable was concordance between the provisional incisional biopsy diagnosis and definitive pathologic resection diagnosis. The secondary outcome variable was type of biopsy error for the discordant cases. Incisional biopsy errors were assessed and grouped into 5 categories: 1) sampling error; 2) insufficient tissue for diagnosis; 3) presence of inflammation making diagnosis difficult; 4) artifact; and 5) pathologist discordance.Results: A total of 272 patients met the inclusion criteria. The study sample had a mean age of 47.4 years and 55.7% were women. Of these cases, 242 (88.9%) were concordant when comparing the biopsy and final resection pathology reports. At histologic evaluation, 60.0% of discordant findings were attributed to sampling error, 23.3% to pathologist discrepancy, 13.3% to insufficient tissue provided in the biopsy specimen, and 3.4% to inflammation obscuring diagnosis. Overall, concordant cases had a larger average biopsy volume (1.53 cm(3)) than discordant cases (0.42 cm(3)).Conclusion: The data collected indicate an 88.9% diagnostic concordance with final pathologic results for incisional oral biopsy diagnoses. Sixty percent of discordance was attributed to sampling error when sampled tissue was not representative of the lesion in toto. Multiple-site biopsy specimens and larger-volume samples allowed for a more accurate diagnosis. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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