Event-related potentials demonstrate deficits in acoustic segmentation in schizophrenia.
Segmentation of the acoustic environment into discrete percepts is an important facet of auditory scene analysis (ASA). Segmentation of auditory stimuli into perceptually meaningful and localizable groups is central to ASA in everyday situations; for example, separation of discrete words from contin...
| Published in: | Schizophrenia Research Vol. 173; no. 1/2; pp. 109 - 116 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Published: |
Elsevier B.V.
May2016
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=114572311&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 114572311 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09209964 3PT jtl: Schizophrenia Research issn: 09209964 maglogo: N pubinfo: dt: May2016 vid: 173 iid: 1/2 pid: 1004 pub: Elsevier B.V. artinfo: ui: 114572311 114572311 NLM27032476 10.1016/j.schres.2016.03.012 NLM27032476 PMC4993213 [Available on 05/01/17] 114572311 ppf: 109 ppct: 7 formats: tig: atl: Event-related potentials demonstrate deficits in acoustic segmentation in schizophrenia. aug: au: Coffman, Brian A. Haigh, Sarah M. Murphy, Tim K. Salisbury, Dean F. affil: Clinical Neurophysiology Research Laboratory, Western Psychiatric Institute & Clinic, University of Pittsburgh School of Medicine, United States sug: subj: Schizophrenia Complications Auditory Perceptual Disorders Physiopathology Auditory Perception Physiology Auditory Perceptual Disorders Etiology Evoked Potentials Physiology Female Young Adult Acoustic Stimulation Statistics Adult Male Analysis of Variance Psychological Tests Electroencephalography Scales Social Readjustment Rating Scale Adult: 19-44 years Female Male ab: Segmentation of the acoustic environment into discrete percepts is an important facet of auditory scene analysis (ASA). Segmentation of auditory stimuli into perceptually meaningful and localizable groups is central to ASA in everyday situations; for example, separation of discrete words from continuous sentences when processing language. This is particularly relevant to schizophrenia, where deficits in perceptual organization have been linked to symptoms and cognitive dysfunction. Here we examined event-related potentials in response to grouped tones to elucidate schizophrenia-related differences in acoustic segmentation. We report for the first time in healthy subjects a sustained potential that begins with group initiation and ends with the last tone of the group. These potentials were reduced in schizophrenia, with the greatest differences in responses to first and final tones. Importantly, reductions in sustained potentials in schizophrenia patients were associated with greater negative symptoms and deficits in IQ, working memory, learning, and social cognition. These results suggest deficits in auditory pattern segmentation in schizophrenia may compound deficits in many higher-order facets of the disorder. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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