Influence of age and sex on the longitudinal relaxation time, T1, of the lung in healthy never-smokers.
Background: As several studies have provided evidence that lung disease affects the T1 of the human lung, our purpose was to investigate the effect of age on the T1-relaxation time in the lungs of healthy never-smokers, including group difference between sexes. Materials and Methods: The Snapshot FL...
| Publicado en: | Journal of Magnetic Resonance Imaging Vol. 43; no. 5; pp. 1250 - 1258 |
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| Autores principales: | , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
May2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=114605941&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 114605941 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10531807 O63 jtl: Journal of Magnetic Resonance Imaging issn: 10531807 maglogo: Y pubinfo: dt: May2016 vid: 43 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 114605941 114605941 NLM26558716 114605941 10.1002/jmri.25085 NLM26558716 114605941 ppf: 1250 ppct: 8 formats: tig: atl: Influence of age and sex on the longitudinal relaxation time, T1, of the lung in healthy never-smokers. aug: au: Kindvall, Simon S.I. Diaz, Sandra Svensson, Jonas Wollmer, Per Slusarczyk, Dariusz Olsson, Lars E. affil: Medical Radiation Physics, Translational Medicine, Lund University, Malmö Sweden sug: subj: Magnetic Resonance Imaging Lung Sex Factors Age Factors Human Young Adult Research Subjects Middle Age Linear Regression Male Blood Volume Regression Female Breath Holding Respiratory Function Tests Aged Adult Smoking Models, Statistical Validation Studies Comparative Studies Evaluation Research Multicenter Studies Middle Aged: 45-64 years Aged: 65+ years Adult: 19-44 years Male Female ab: Background: As several studies have provided evidence that lung disease affects the T1 of the human lung, our purpose was to investigate the effect of age on the T1-relaxation time in the lungs of healthy never-smokers, including group difference between sexes. Materials and Methods: The Snapshot FLASH pulse sequence (inversion recovery with multiple gradient echo read-outs) was used to quantify lung T1 in 30 healthy never-smoking volunteers at 1.5 Tesla. Measurements were performed under breathhold of a tidal inspiration. Additionally, subjects underwent clinical MRI and pulmonary function tests. A linear regression model of T1 as a function of age and sex was tested. Results: The slope of lung T1 at tidal end-inspiration as a function of age was statistically different between males and females (P < 0.001). In a linear regression model of T1 as a function of age and sex, females have slope of -4.1 ms/year (95% confidence interval [CI], [-5.2, -3.0]) at P < 0.001, and males -0.064 ms/year (95% CI, [-1.2, 1.1]) at P = 0.9, with a whole model R(2) = 0.83. Conclusion: The observed dependencies of lung T1 on age and sex are here attributed to a previously reported difference in blood T1 between sexes, and a previously reported decrease of pulmonary blood volume with increasing age. This may have implications for the interpretation of lung T1 measurements in both healthy individuals and patients. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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