Experimental Inferential Structure Determination of Ensembles for Intrinsically Disordered Proteins.

We develop a Bayesian approach to determine the most probable structural ensemble model from candidate structures for intrinsically disordered proteins (IDPs) that takes full advantage of NMR chemical shifts and J-coupling data, their known errors and variances, and the quality of the theoretical ba...

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Publicado en:	Journal of the American Chemical Society Vol. 138; no. 13; pp. 4530 - 4539
Autores principales:	Brookes, David H., Head-Gordon, Teresa
Formato:	Artículo
Publicado:	American Chemical Society 4/6/2016
Materias:	Protein research Nuclear magnetic resonance Mathematical optimization Boltzmann's equation Conformational analysis
Acceso en línea:	Ver este registro en EBSCOhost