Effects of tretinoin on wound healing in aged skin.
Aged and adult populations have differences in the structural, biological, and healing properties of skin. Comparative studies of healing under the influence of retinoids in both these populations are very important and, to the best of our knowledge, have not been performed to date. The purpose of t...
| Publicado en: | Wound Repair & Regeneration Vol. 24; no. 2; pp. 411 - 418 |
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| Autores principales: | , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Mar/Apr2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=114817076&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 114817076 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10671927 DPV jtl: Wound Repair & Regeneration issn: 10671927 maglogo: Y pubinfo: dt: Mar/Apr2016 vid: 24 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 114817076 114817076 114817076 10.1111/wrr.12417 114817076 ppf: 411 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Effects of tretinoin on wound healing in aged skin. aug: au: de Campos Peseto, Danielle Carmona, Erica Vilaça Silva, Kellyn Cristina da Guedes, Flavia Roberta Valente Hummel Filho, Fernando Martinez, Natalia Peres Pereira, José Aires Rocha, Thalita Priolli, Denise Gonçalves affil: Sao Francisco University Medical School, Bragança Paulista Sao Paulo, Brazil sug: subj: Skin Aging Drug Effects Tretinoin Therapeutic Use Wound Healing Tretinoin Pharmacodynamics Animal Studies Rats Models, Biological Tretinoin Administration and Dosage Administration, Topical Analysis of Variance Data Analysis Software Mann-Whitney U Test T-Tests Collagen Funding Source ab: Aged and adult populations have differences in the structural, biological, and healing properties of skin. Comparative studies of healing under the influence of retinoids in both these populations are very important and, to the best of our knowledge, have not been performed to date. The purpose of this study was to compare the activities of topical tretinoin in aged and adult animal models of wound healing by secondary intention. Male aged rats (24 months old, n = 7) and adult rats (6 months old, n = 8) were used. The rats were assigned to the following groups according to the dates on which wound samples were excised (day 14 or 21 after model creation): treated group, control group, and naive group. Topical application of tretinoin cream was used only on the proximal wound and was applied daily for 7 days. Wound healing areas were measured using metal calipers, and morphological analysis was performed. Slides were stained with Hematoxylin and Eosin, Masson's trichrome, and periodic acid-Schiff stains. Statistical analysis adopted a 5% coefficient for rejection of the null hypothesis. Although aged animals showed skin repair, complete reepithelialization was found on day 21 in some animals of both groups (treated and control). In aged rats, the wound area was significantly smaller in treated wounds than in untreated wounds, resulting in a larger scar area compared with the adult group. When treated wounds were compared, no differences were found between the wound areas in adult and aged rats. As expected, the collagen concentration was higher in normal skin from adult rats than in normal skin from aged animals, but there was no difference when aged skin was treated with tretinoin. These results indicate that tretinoin increases collagen synthesis in aged skin and returns the healing process to a normal state of skin healing. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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