Burn depth assessments by photoacoustic imaging and laser Doppler imaging.
Diagnosis of burn depths is crucial to determine the treatment plan for severe burn patients. However, an objective method for burn depth assessment has yet to be established, although a commercial laser Doppler imaging (LDI) system is used limitedly. We previously proposed burn depth assessment bas...
| Published in: | Wound Repair & Regeneration Vol. 24; no. 2; pp. 349 - 356 |
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| Main Authors: | , , , , , , , , , |
| Format: | diagnostic images pictorial research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
Mar/Apr2016
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=114817089&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 114817089 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10671927 DPV jtl: Wound Repair & Regeneration issn: 10671927 maglogo: Y pubinfo: dt: Mar/Apr2016 vid: 24 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 114817089 114817089 114817089 10.1111/wrr.12374 114817089 ppf: 349 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Burn depth assessments by photoacoustic imaging and laser Doppler imaging. aug: au: Ida, Taiichiro Iwazaki, Hideaki Kawaguchi, Yasushi Kawauchi, Satoko Ohkura, Tsuyako Iwaya, Keiichi Tsuda, Hitoshi Saitoh, Daizoh Sato, Shunichi Iwai, Toshiaki affil: New Concept Product Initiative, Advantest Corporation sug: subj: Burns Wound Assessment Equipment and Supplies Wound Assessment Methods Animal Studies Rats Models, Biological Severity of Injury Perfusion Japan Photography Histology Biophysical Instruments ab: Diagnosis of burn depths is crucial to determine the treatment plan for severe burn patients. However, an objective method for burn depth assessment has yet to be established, although a commercial laser Doppler imaging (LDI) system is used limitedly. We previously proposed burn depth assessment based on photoacoustic imaging (PAI), in which thermoelastic waves originating from blood under the burned tissue are detected, and we showed the validity of the method by experiments using rat models with three different burn depths: superficial dermal burn, deep dermal burn and deep burn. On the basis of those results, we recently developed a real-time PAI system for clinical burn diagnosis. Before starting a clinical trial, however, there is a need to reveal more detailed diagnostic characteristics, such as linearity and error, of the PAI system as well as to compare its characteristics with those of an LDI system. In this study, we prepared rat models with burns induced at six different temperatures from 70 to 98 °C, which showed a linear dependence of injury depth on the temperature. Using these models, we examined correlations of signals obtained by PAI and LDI with histologically determined injury depths and burn induction temperatures at 48 hours postburn. We found that the burn depths indicated by PAI were highly correlative with histologically determined injury depths (depths of viable vessels) as well as with burn induction temperatures. Perfusion values measured by LDI were less correlative with these parameters, especially for burns induced at higher temperatures, being attributable to the limited detectable depth for light involving a Doppler shift in tissue. In addition, the measurement errors in PAI were smaller than those in LDI. On the basis of these results, we will be able to start clinical studies using the present PAI system. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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