Molecular imaging with Tc-MIBI and molecular testing for mutations in differentiating benign from malignant follicular neoplasm: a prospective comparison.
Purpose: To compare mutation analysis of cytology specimens and Tc-MIBI thyroid scintigraphy for differentiating benign from malignant thyroid nodules in patients with a cytological reading of follicular neoplasm. Methods: Patients ≥18 years of age with a solitary hypofunctioning thyroid nodule (≥10...
| Published in: | European Journal of Nuclear Medicine & Molecular Imaging Vol. 43; no. 6; pp. 1018 - 1027 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Jun2016
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=114818194&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 114818194 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16197070 NPC jtl: European Journal of Nuclear Medicine & Molecular Imaging issn: 16197070 maglogo: N pubinfo: dt: Jun2016 vid: 43 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 114818194 10.1007/s00259-015-3285-1 114818194 ppf: 1018 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Molecular imaging with Tc-MIBI and molecular testing for mutations in differentiating benign from malignant follicular neoplasm: a prospective comparison. aug: au: Giovanella, L. Campenni, A. Treglia, G. Verburg, F. Trimboli, P. Ceriani, L. Bongiovanni, M. affil: Department of Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Via Ospedale 12 6500 Bellinzona Switzerland sug: ab: Purpose: To compare mutation analysis of cytology specimens and Tc-MIBI thyroid scintigraphy for differentiating benign from malignant thyroid nodules in patients with a cytological reading of follicular neoplasm. Methods: Patients ≥18 years of age with a solitary hypofunctioning thyroid nodule (≥10 mm), normal thyrotropin and calcitonin levels, and a cytological diagnosis of follicular neoplasm were prospectively enrolled. Mutation analysis and Tc-MIBI scintigraphy were performed and patients were subsequently operated on to confirm or exclude a malignant lesion. Mutations for KRAS, HRAS and NRAS and for BRAF and translocations of PAX8/PPARγ, RET/PTC1 and RET/PTC3 were investigated. Static thyroid scintigraphic images were acquired 10 and 60 min after intravenous injection of 200 MBq of Tc-MIBI and visually assessed. Additionally, the MIBI washout index was calculated using a semiquantitative method. Results: In our series, 26 % of nodules with a follicular pattern on cytology were malignant with a prevalence of follicular carcinomas. Tc-MIBI scintigraphy was found to be significantly more accurate (positive likelihood ratio 4.56 for visual assessment and 12.35 for semiquantitative assessment) than mutation analysis (positive likelihood ratio 1.74). A negative Tc-MIBI scan reliably excluded malignancy. Conclusion: In patients with a thyroid nodule cytologically diagnosed as a follicular proliferation, semiquantitative analysis of Tc-MIBI scintigraphy should be the preferred method for differentiating benign from malignant nodules. It is superior to molecular testing for the presence of differentiated thyroid cancer-associated mutations in fine-needle aspiration cytology sample material. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|